Overcoming Resistance to Immune Checkpoint Therapy in PTEN-Null Prostate Cancer by Intermittent Anti-PI3Kα/β/δ Treatment

Scientists found that intermittent but not daily dosing of a PI3Kα/β/δ inhibitor, BAY1082439, on Pten-null prostate cancer models could overcome immune checkpoint therapy resistance and unleash CD8+ T cell-dependent anti-tumor immunity in vivo.
[Nature Communications]
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Critically Ill COVID-19 Patients Exhibit Peripheral Immune Profiles Predictive of Mortality and Reflective of SARS-CoV-2 Viral Burden in the Lung

Scientists presented high-dimensional profiling of blood and respiratory samples in severe COVID-19 patients to examine the association between cell-linked molecular features and mortality outcomes.
[Cell Reports Medicine]
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Sequential Modulation of the Wnt/β-Catenin Signaling Pathway Enhances Tumor-Intrinsic MHC I Expression and Tumor Clearance

Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence
[Gynecological Oncology]
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TM4SF5-Dependent Crosstalk between Hepatocytes and Macrophages to Reprogram the Inflammatory Environment

Scientists investigated the role of TM4SF5 in communication between hepatocytes and macrophages and its possible influence on the inflammatory microenvironment that may lead to nonalcoholic fatty liver disease.
[Cell Reports]
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Interleukin-30 Feeds Breast Cancer Stem Cells via CXCL10 and IL23 Autocrine Loops and Shapes Immune Contexture and Host Outcome

Human and murine breast CSCs were tested for their production of and response to IL30 by using flow cytometry, confocal microscopy, proliferation and sphere-formation assays, and PCR array.
[Journal For Immunotherapy of Cancer]
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Regulation of Intestinal Immunity and Tissue Repair by Enteric Glia

Scientists uncovered important roles of enteric glial cells in intestinal homeostasis, immunity and tissue repair. They demonstrated that infection of mice with Heligmosomoides polygyrus led to enteric gliosis and the upregulation of an interferon gamma gene signature.
[Nature]
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Oxaliplatin Facilitates Tumor-Infiltration of T Cells and Natural-Killer Cells for Enhanced Tumor Immunotherapy in Lung Cancer Mode

Subcutaneous A549 lung cancer and murine Lewis lung carcinoma (LLC) models were constructed, which were further intravenously injected with platinum-based drugs or concomitant administrated with anti-PD-1 antibody and or anti-NKG2D antibody.
[Anti-Cancer Drugs]
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Cytosolic-DNA-Mediated STING-Dependent Inflammation Contributes to the Progression of Psoriasis

Stimulator of IFN genes (STING) is a universal receptor that recognizes cytosolic DNA and triggers innate immune activation. Investigators elucidated the role of STING in the inflammation during psoriasis.
[Journal of Investigative Dermatology]
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CXCL9 as a Key Biomarker of Vitiligo Activity and Prediction of the Success of Cultured Melanocyte Transplantation

Scientists investigated the potential biomarkers of vitiligo by evaluating the disease activity and curative effect of autologous cultured pure melanocyte transplantation on patients.
[Scientific Reports]
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Role of CXCL10 in the Progression of In Situ to Invasive Carcinoma of the Breast

Scientists performed immune profiling to compare immune-related gene expression between ductal carcinoma in situ and invasive carcinoma of the breast using nCounter PanCancer immune Profiling Panel and found that CXCL10 was the most significant gene that had the highest difference in expression between them.
[Scientific Reports]
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Pro-Inflammatory β Cell Small Extracellular Vesicles Induce β Cell Failure through Activation of the CXCL10/CXCR3 Axis in Diabetes

Scientists reported that pro-inflammatory β cell small extracellular vesicles induced β cell dysfunction, promoted a pro-inflammatory islet transcriptome, and enhanced recruitment of CD8+ T cells and macrophages.
[Cell Reports]
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