Investigators showed that cyclin-dependent kinases 4 and 6 (CDK4/6i) could enhance efficacy of T cell-based therapies, such as adoptive T cell transfer or T cell-activating antibodies anti-OX40/anti-4-1BB, in murine breast cancer models.
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Uzhachenko, R. V., Bharti, V., Ouyang, Z., Blevins, A., Mont, S., Saleh, N., Lawrence, H. A., Shen, C., Chen, S.-C., Ayers, G. D., DeNardo, D. G., Arteaga, C., Richmond, A., & Vilgelm, A. E. (2021). Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108944 Cite
A progressive and consistent reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngeneic mice.
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Baloche, V., Rivière, J., Tran, T. B. T., Gelin, A., Bawa, O., Signolle, N., Diop, M. K., Dessen, P., Beq, S., David, M., & Busson, P. (2021). Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model. Scientific Reports, 11(1), 5227. https://doi.org/10.1038/s41598-021-84270-1 Cite
Scientists developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate.
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Duckworth, B. C., Lafouresse, F., Wimmer, V. C., Broomfield, B. J., Dalit, L., Alexandre, Y. O., Sheikh, A. A., Qin, R. Z., Alvarado, C., Mielke, L. A., Pellegrini, M., Mueller, S. N., Boudier, T., Rogers, K. L., & Groom, J. R. (2021). Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands. Nature Immunology, 1–15. https://doi.org/10.1038/s41590-021-00878-5 Cite
Human umbilical cord mesenchymal stem cells were used to deliver reovirus using in vitro and in vivo models.
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Researchers focus on toll-like receptor-3 (TLR3) that was activated by double-strand RNA and promoted neuroinflammation.
[Cell Death & Disease]
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Boccazzi, M., Van Steenwinckel, J., Schang, A.-L., Faivre, V., Le Charpentier, T., Bokobza, C., Csaba, Z., Verderio, C., Fumagalli, M., Mani, S., & Gressens, P. (2021). The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation. Cell Death & Disease, 12(2), 1–12. https://doi.org/10.1038/s41419-021-03446-9 Cite
Researchers investigated whether and how N-803 improves hematopoietic progenitor cell-natural killer cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice.
[Cancer Immunology Immunotherapy]
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Applying multimodal single-cell analyses, investigators elucidated a heterogeneous but spatially defined central nervous system (CNS)-myeloid response during brain metastasis (br-met) outgrowth. We found Ccr2+ bone-marrow-derived myeloid cells minimally influenced br-met while CNS-myeloid promoted br-met outgrowth.
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Guldner, I. H., Wang, Q., Yang, L., Golomb, S. M., Zhao, Z., Lopez, J. A., Brunory, A., Howe, E. N., Zhang, Y., Palakurthi, B., Barron, M., Gao, H., Xuei, X., Liu, Y., Li, J., Chen, D. Z., Landreth, G. E., & Zhang, S. (2020). CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.09.064 Cite
Researchers showed that inhibition of N6‐methyladenosine mRNA modification by depletion of methyltransferases enhanced response to anti‐PD‐1 treatment in pMMR‐MSI‐L colorectal cancer and melanoma.
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Researchers investigated whether the down-regulation of Scm-like with four mbt domains 2 (SFMBT2) regulated the infiltration of preadipocytes and tumor-associated macrophages in prostate cancer.
Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
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Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite
Investigators performed methylation loci fine-mapping to search the top signals in the entire CYP2S1 gene region, and further carried out gene expression assay, cell proliferation, apoptosis, differentiation and migration in CYP2S1 overexpressed (CYP2S1over) and silenced human keratinocytes.
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