Metabolic Modulation by CDK4/6 Inhibitor Promotes Chemokine-Mediated Recruitment of T Cells Into Mammary Tumors

Investigators showed that cyclin-dependent kinases 4 and 6 (CDK4/6i) could enhance efficacy of T cell-based therapies, such as adoptive T cell transfer or T cell-activating antibodies anti-OX40/anti-4-1BB, in murine breast cancer models.
[Cell Reports]
Uzhachenko, R. V., Bharti, V., Ouyang, Z., Blevins, A., Mont, S., Saleh, N., Lawrence, H. A., Shen, C., Chen, S.-C., Ayers, G. D., DeNardo, D. G., Arteaga, C., Richmond, A., & Vilgelm, A. E. (2021). Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108944 Cite
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Serial Transplantation Unmasks Galectin-9 Contribution to Tumor Immune Escape in the MB49 Murine Model

A progressive and consistent reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngeneic mice.
[Scientific Reports]
Baloche, V., Rivière, J., Tran, T. B. T., Gelin, A., Bawa, O., Signolle, N., Diop, M. K., Dessen, P., Beq, S., David, M., & Busson, P. (2021). Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model. Scientific Reports, 11(1), 5227. https://doi.org/10.1038/s41598-021-84270-1 Cite
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Effector and Stem-Like Memory Cell Fates Are Imprinted in Distinct Lymph Node Niches Directed by CXCR3 Ligands

Scientists developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate.
[Nature Immunology]
Duckworth, B. C., Lafouresse, F., Wimmer, V. C., Broomfield, B. J., Dalit, L., Alexandre, Y. O., Sheikh, A. A., Qin, R. Z., Alvarado, C., Mielke, L. A., Pellegrini, M., Mueller, S. N., Boudier, T., Rogers, K. L., & Groom, J. R. (2021). Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands. Nature Immunology, 1–15. https://doi.org/10.1038/s41590-021-00878-5 Cite
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Mesenchymal Stem Cell Carriers Enhance Antitumor Efficacy Induced by Oncolytic Reovirus in Acute Myeloid Leukemia

Human umbilical cord mesenchymal stem cells were used to deliver reovirus using in vitro and in vivo models.
[International Immunopharmacology]
Wang, X., Yang, Y., Wang, N., Wu, X., Xu, J., Zhou, Y., Zhao, X., & He, Z. (2021). Mesenchymal stem cell carriers enhance antitumor efficacy induced by oncolytic reovirus in acute myeloid leukemia. International Immunopharmacology, 94, 107437. https://doi.org/10.1016/j.intimp.2021.107437 Cite
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The Immune-Inflammatory Response of Oligodendrocytes in a Murine Model of Preterm White Matter Injury: The Role of TLR3 Activation

Researchers focus on toll-like receptor-3 (TLR3) that was activated by double-strand RNA and promoted neuroinflammation.
[Cell Death & Disease]
Boccazzi, M., Van Steenwinckel, J., Schang, A.-L., Faivre, V., Le Charpentier, T., Bokobza, C., Csaba, Z., Verderio, C., Fumagalli, M., Mani, S., & Gressens, P. (2021). The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation. Cell Death & Disease, 12(2), 1–12. https://doi.org/10.1038/s41419-021-03446-9 Cite
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IL-15 Superagonist N-803 Improves IFNγ Production and Killing of Leukemia and Ovarian Cancer Cells by CD34+ Progenitor-Derived NK Cells

Researchers investigated whether and how N-803 improves hematopoietic progenitor cell-natural killer cell functionality in leukemia and ovarian cancer (OC) models in vitro and in vivo in OC-bearing immunodeficient mice.
[Cancer Immunology Immunotherapy]
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CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

Applying multimodal single-cell analyses, investigators elucidated a heterogeneous but spatially defined central nervous system (CNS)-myeloid response during brain metastasis (br-met) outgrowth. We found Ccr2+ bone-marrow-derived myeloid cells minimally influenced br-met while CNS-myeloid promoted br-met outgrowth.
[Cell]
Guldner, I. H., Wang, Q., Yang, L., Golomb, S. M., Zhao, Z., Lopez, J. A., Brunory, A., Howe, E. N., Zhang, Y., Palakurthi, B., Barron, M., Gao, H., Xuei, X., Liu, Y., Li, J., Chen, D. Z., Landreth, G. E., & Zhang, S. (2020). CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.09.064 Cite
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m6A RNA Methyltransferases METTL3/14 Regulate Immune Responses to Anti-PD-1 Therapy

Researchers showed that inhibition of N6‐methyladenosine mRNA modification by depletion of methyltransferases enhanced response to anti‐PD‐1 treatment in pMMR‐MSI‐L colorectal cancer and melanoma.
[EMBO Journal]
Wang, L., Hui, H., Agrawal, K., Kang, Y., Li, N., Tang, R., Yuan, J., & Rana, T. M. (2020). m6A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy. The EMBO Journal, n/a(n/a), e104514. https://doi.org/10.15252/embj.2020104514 Cite
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SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer

Researchers investigated whether the down-regulation of Scm-like with four mbt domains 2 (SFMBT2) regulated the infiltration of preadipocytes and tumor-associated macrophages in prostate cancer.
[Cancers]
Gwak, J., Jeong, H., Lee, K., Shin, J. Y., Sim, T., Na, J., Kim, J., & Ju, B.-G. (2020). SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer. Cancers, 12(9), 2718. https://doi.org/10.3390/cancers12092718 Cite
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Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 Axes Contributes to Antitumor Effects in a Mouse Model of Malignant Glioma

Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
[Scientific Reports]
Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite
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CYP2S1 Might Regulate Proliferation and Immune Response of Keratinocyte in Psoriasis

Investigators performed methylation loci fine-mapping to search the top signals in the entire CYP2S1 gene region, and further carried out gene expression assay, cell proliferation, apoptosis, differentiation and migration in CYP2S1 overexpressed (CYP2S1over) and silenced human keratinocytes.
[Epigenetics]
Sheng, Y., Wen, L., Zheng, X., Li, M., Wang, D., Chen, S., Li, R., Tang, L., & Zhou, F. (2020). CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis. Epigenetics, 0(0), 1–11. https://doi.org/10.1080/15592294.2020.1814486 Cite
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