CXCL10

[Cell Reports Medicine] Scientists presented high-dimensional profiling of blood and respiratory samples in severe COVID-19 patients to examine the association between cell-linked molecular features and mortality outcomes.

[Gynecological Oncology] Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence

[Cell Reports] Scientists investigated the role of TM4SF5 in communication between hepatocytes and macrophages and its possible influence on the inflammatory microenvironment that may lead to nonalcoholic fatty liver disease.

[Journal For Immunotherapy of Cancer] Human and murine breast CSCs were tested for their production of and response to IL30 by using flow cytometry, confocal microscopy, proliferation and sphere-formation assays, and PCR array.

[Nature] Scientists uncovered important roles of enteric glial cells in intestinal homeostasis, immunity and tissue repair. They demonstrated that infection of mice with Heligmosomoides polygyrus led to enteric gliosis and the upregulation of an interferon gamma gene signature.

[Anti-Cancer Drugs] Subcutaneous A549 lung cancer and murine Lewis lung carcinoma (LLC) models were constructed, which were further intravenously injected with platinum-based drugs or concomitant administrated with anti-PD-1 antibody and or anti-NKG2D antibody.