EGFR

[Journal of Experimental Medicine] Optically clear immunocompromised zebrafish were engrafted with fluorescent-labeled human cancers along with CAR T cells, bispecific T cell engagers, and antibody peptide epitope conjugates, allowing real-time single-cell visualization of T cell–based immunotherapies in vivo.

[Scientific Reports] Researchers created three different types of chimeric MrNV VLPs that had specificity toward the epidermal growth factor receptor (EGFR), a cancer cell biomarker, by incorporating the EGFR-specific GE11 peptide at three different locations within the host cell recognition site of the capsid.

[Scientific Reports] Scientists screened for targets for the treatment of ischemia–reperfusion injury using a combination of shRNA and drug library analyses in HL-1 mouse cardiomyocytes subjected to hypoxia and reoxygenation.

[Molecular Medicine Reports] Scientists elucidated the functions of miR‑125a‑5p and miR‑7 in vascular smooth muscle cells and investigated the associated molecular mechanisms.

[npj Breast Cancer] Exogenous leptin abrogated tamoxifen-mediated growth inhibition and potentiated breast tumor growth even in the presence of tamoxifen.

[Oncogene] Researchers found that NDRG1 enhanced the sensitivity of cetuximab in colorectal cancer cell lines by inhibiting the expression of epidermal growth factor receptor (EGFR); blocking EGFR phosphorylation and reducing the EGFR distribution in the cell membrane, cytoplasm and nucleus.