EMT

[Journal of Cellular Biochemistry] Scientists summarize the current understanding of the regulatory mechanisms of T-box genes in cancer, epithelial-mesenchymal transition, and CSCs, and discuss the implications of targeting T-box genes as anticancer therapeutics.

[Biochemical Pharmacology] MICAL1 has been reported to be involved in the malignant processes of several types of cancer cells, however, the roles of MICAL1 in colorectal cancer (CRC) have not been well-characterized. Researchers investigated the cellular functions and molecular mechanisms of MICAL1 in CRCs.

[Cell Death Discovery] Researchers elucidated the function of androgen receptor (AR) in prostate cancer (PCa) and suggested that AR positively regulated eIF5A2 expression in androgen-dependent cells, and stimulation of AR expression and signaling in prostate tumors promoted PCa metastasis.

[andrology] CCK-8, colony formation, transwell, tube formation and flow cytometry assays were applied to assess cell proliferation, motility, angiogenesis, cell cycle distribution and apoptosis.

[Evidence-Based Complementary and Alternative Medicine] The expression level of relative proteins in mTOR pathway was detected by western blot assay to investigate the mechanism of Qingjie Fuzheng granule effect on colorectal cancer cells.

[Scientific Reports] LncRNAs play critical roles in the tumorigenesis of glioblastoma (GBM) through regulation of various cancer-related genes and signaling pathways. Researchers focused on the essential role of EMT and identified 78 upregulated EMT-related genes in GBM through differential expression analysis.