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EMT
Prostate Cell News
GATA Binding Protein 5-Mediated Transcriptional Activation of Transmembrane Protein 100 Suppresses Cell Proliferation, Migration and Epithelial-to-Mesenchymal Transition in Prostate Cancer DU145 Cells
[Bioengineered] The authors uncovered the role of GATA binding protein 5-mediated activation of transmembrane protein 100 in the proliferation, migration and epithelial-to-mesenchymal transition of prostate cancer cells.
Intestinal Cell News
RBMS1 Promotes Gastric Cancer Metastasis through Autocrine IL-6/JAK2/STAT3 Signaling
[Cell Death & Disease] Researchers explored a prognostic model for the estimation of tumor-associated mortality in gastric cancer (GC) patients and revealed the RNA-binding protein RBMS1 as a candidate promoter gene for GC metastasis by analyzing GOBO and oncomine high-throughput sequencing datasets for 408 GC patients.
Pulmonary Cell News
The Cancer/Testis Antigen HORMAD1 Mediates Epithelial–Mesenchymal Transition to Promote Tumor Growth and Metastasis by Activating the Wnt/β-Catenin Signaling Pathway in Lung Cancer
[Cell Death Discovery] The authors demonstrated that HORMAD1 promotes the proliferation, migration and invasion of lung cancer cells both in vitro and in vivo by inducing epithelial–mesenchymal transition.
Cancer Stem Cell News
TGFβ Selects for Pro-stemness over Pro-invasive Phenotypes during Cancer Cell Epithelial–Mesenchymal Transition
[Molecular Oncology] Whether TGFβ promoted stemness and invasiveness simultaneously via epithelial-mesenchymal transition remained unclear. They established a breast cancer cell model expressing red fluorescent protein under the E-cadherin promoter.
Cancer Stem Cell News
Low-Temperature Plasma-Activated Medium Inhibited Proliferation and Progression of Lung Cancer by Targeting the PI3K/Akt and MAPK Pathways
[Oxidative Medicine and Cellular Longevity] Scientists explored the effect of the plasma-activated medium on lung cancer cells in vitro and in vivo by using a 3D cell culture model.
Pancreatic Cell News
Isoforms of the Orphan Nuclear Receptor COUP-TFII Differentially Modulate Pancreatic Cancer Progression
[International Journal of Oncology] It was demonstrated that COUP‑TFII_V2 naturally occured in PDAC cells and in primary samples, where its expression was consistent with shorter overall survival and peripheral invasion.