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GATA Binding Protein 5-Mediated Transcriptional Activation of Transmembrane Protein 100 Suppresses Cell Proliferation, Migration and Epithelial-to-Mesenchymal Transition in Prostate Cancer DU145 Cells

[Bioengineered] The authors uncovered the role of GATA binding protein 5-mediated activation of transmembrane protein 100 in the proliferation, migration and epithelial-to-mesenchymal transition of prostate cancer cells.

RBMS1 Promotes Gastric Cancer Metastasis through Autocrine IL-6/JAK2/STAT3 Signaling

[Cell Death & Disease] Researchers explored a prognostic model for the estimation of tumor-associated mortality in gastric cancer (GC) patients and revealed the RNA-binding protein RBMS1 as a candidate promoter gene for GC metastasis by analyzing GOBO and oncomine high-throughput sequencing datasets for 408 GC patients.

The Cancer/Testis Antigen HORMAD1 Mediates Epithelial–Mesenchymal Transition to Promote Tumor Growth and Metastasis by Activating the Wnt/β-Catenin Signaling Pathway in Lung Cancer

[Cell Death Discovery] The authors demonstrated that HORMAD1 promotes the proliferation, migration and invasion of lung cancer cells both in vitro and in vivo by inducing epithelial–mesenchymal transition.

TGFβ Selects for Pro-stemness over Pro-invasive Phenotypes during Cancer Cell Epithelial–Mesenchymal Transition

[Molecular Oncology] Whether TGFβ promoted stemness and invasiveness simultaneously via epithelial-mesenchymal transition remained unclear. They established a breast cancer cell model expressing red fluorescent protein under the E-cadherin promoter.

Low-Temperature Plasma-Activated Medium Inhibited Proliferation and Progression of Lung Cancer by Targeting the PI3K/Akt and MAPK Pathways

[Oxidative Medicine and Cellular Longevity] Scientists explored the effect of the plasma-activated medium on lung cancer cells in vitro and in vivo by using a 3D cell culture model.

Isoforms of the Orphan Nuclear Receptor COUP-TFII Differentially Modulate Pancreatic Cancer Progression

[International Journal of Oncology] It was demonstrated that COUP‑TFII_V2 naturally occured in PDAC cells and in primary samples, where its expression was consistent with shorter overall survival and peripheral invasion.

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