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Xanthomicrol Suppresses Human Hepatocellular Carcinoma Cells Migration and Invasion Ability via Îœu-Opioid Receptor

[Journal of Pharmacy and Pharmacology] Investigators explored Xanthomicrol’s effects on migration and invasion ability of the human human hepatocellular carcinoma Huh7 cell line.

A Novel Chemical Inhibitor Suppresses Breast Cancer Cell Growth and Metastasis through Inhibiting HPIP Oncoprotein

[Cell Death Discovery] The authors screened compounds inhibiting breast cancer cell proliferation with hematopoietic PBX-interacting protein (HPIP) fused with green fluorescent protein as a reporter. A novel agent named TXX-1-10 derived from rimonabant was discovered to reduce HPIP expression and had greater inhibitory effects on breast cancer cell growth and metastasis in vitro and in vivo than rimonabant.

SERS Quantification of Galunisertib Delivery in Colorectal Cancer Cells by Plasmonic-Assisted Diatomite Nanoparticles

[Small] The multifunctional capability of a proposed nanosystem is demonstrated by investigating the efficient Galunisertib delivery, the enhanced epithelial-to-mesenchymal transition reversion in colorectal cancer cells and the intracellular quantification of drug release with a sub-femtogram resolution by surface-enhanced Raman spectroscopy (SERS).

Mutant p53 Attenuates Oxidative Phosphorylation and Facilitates Cancer Stemness through Downregulating microRNA-200c-PCK2 Axis in Basal-Like Breast Cancer

[Molecular Cancer Research] The authors demonstrated that CRISPR-mediated knockout of miR-200c induced metabolic features similar to the metabolic rewiring caused by p53 hot-spot mutations, and that impairing this metabolic reprogramming interfered with miR-200c deficiency-induced stemness and transformation.

Progression of Melanoma Is Suppressed by Targeting All Transforming Growth Factor-β Isoforms with an FC Chimeric Receptor

[Oncology Reports] Scientists revealed that TβRI‑TβRII‑Fc chimeric receptor suppressed the epithelial‑mesenchymal transition program in melanoma cells in vitro induced by any of the three TGF‑β isoforms, as revealed by decreased expression of mesenchymal markers.

CD90low Glioma-Associated Mesenchymal Stromal/Stem Cells Promote Temozolomide Resistance by Activating FOXS1-Mediated Epithelial-Mesenchymal Transition in Glioma Cells

[Stem Cell Research & Therapy] Scientists explored the effect and mechanism of glioma-associated MSCs on resistance to temozolomide in glioma cells.

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