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EMT

Comprehensive Profiling of Novel Epithelial–Mesenchymal Transition Mediators and Their Clinical Significance in Colorectal Cancer

[Scientific Reports] To comprehensively profile epithelial–mesenchymal transition (EMT)-related genes in colorectal cancer, investigators quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it “mesenchymal score.”

Identification of Hepatic Fibrosis Inhibitors through Morphometry Analysis of a Hepatic Multicellular Spheroids Model

[Scientific Reports] Scientists established liver fibrosis models using multicellular tumor spheroids (MCTSs) composed of hepatocellular carcinoma (HCC) and stromal cells such as fibroblasts (WI38), hepatic stellate cells (LX2), and endothelial cells (HUVEC) seeded at constant ratios.

MicroRNA-200c Restoration Reveals a Cytokine Profile to Enhance M1 Macrophage Polarization in Breast Cancer

[npj Breast Cancer] To determine how TNBC suppresses antitumor macrophages, scientists used microRNA-200c, a powerful repressor of epithelial-to-mesenchymal transition, to drive mesenchymal-like mouse mammary carcinoma and human TNBC cells toward a more epithelial state.

Systemic Metastasis-Targeted Nanotherapeutic Reinforces Tumor Surgical Resection and Chemotherapy

[Nature Communications] Investigators designed a systemic metastasis-targeted nanotherapeutic (H@CaPP) to hinder the multiple steps of tumor metastasis. H@CaPP efficiently inhibited tumor metastasis and prolonged overall survival of 4T1 mammary tumor-bearing mice.

Epithelial-Mesenchymal Transition Sensitizes Breast Cancer Cells to Cell Death via the Fungus-Derived Sesterterpenoid Ophiobolin A

[Scientific Reports] Using a model of experimentally induced epithelial-mesenchymal transition (EMT) in human mammary epithelial cells, researchers demonstrated that breast cancer cells enriched for EMT features were more sensitive to cytotoxicity induced by ophiobolin A.

ID4 Predicts Poor Prognosis and Promotes BDNF-Mediated Oncogenesis of Colorectal Cancer

[Carcinogenesis] The expression of Inhibitor of DNA binding and cell differentiation 4 (ID4), but not other ID family proteins, was enriched in LGR5-high colon cancer stem cells.

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