Establishment of Intestinal Organoid Cultures Modeling Injury-Associated Epithelial Regeneration

Researchers established a novel intestinal organoid culture system composed of 8 components, mainly including VPA, EPZ6438, LDN193189, and R-Spondin 1 conditioned medium, which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury.
[Cell Research]
Qu, M., Xiong, L., Lyu, Y., Zhang, X., Shen, J., Guan, J., Chai, P., Lin, Z., Nie, B., Li, C., Xu, J., & Deng, H. (2021). Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration. Cell Research, 1–13. https://doi.org/10.1038/s41422-020-00453-x Cite
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