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EPZ6438

Feedback Activation of NF-KB Signaling Leads to Adaptive Resistance to EZH2 Inhibitors in Prostate Cancer Cells

[Cancer Cell International] Scientists revealed a EZH2-SOX9-TNFRSF11A axis in the regulation of activity of NF-κB signaling in prostate cancer cells.

Chromatin Remodeling by the Histone Methyltransferase EZH2 Drives Lung Pre-malignancy and Is a Target for Cancer Prevention

[Clinical Epigenetics] Tobacco carcinogen transformed human bronchial epithelial lines were characterized for cytosine DNA methylation, transcriptome reprogramming, and the effect of inhibiting EZH2 and G9a on the transformed phenotype. The effects of targeting EZH2 and G9a on lung cancer prevention was assessed in the A/J mouse lung tumor model.

Establishment of Intestinal Organoid Cultures Modeling Injury-Associated Epithelial Regeneration

[Cell Research] Researchers established a novel intestinal organoid culture system composed of 8 components, mainly including VPA, EPZ6438, LDN193189, and R-Spondin 1 conditioned medium, which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury.

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