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ERK2

Tpl2 Contributes to IL-1β-Induced IL-8 Expression via ERK1/2 Activation in Canine Dermal Fibroblasts

[PLoS One] Investigators established a model for interleukin 1β (IL-1β)-induced dermatitis and investigated mitogen-activated protein kinase signaling pathways in IL-1β-induced interleukin 8 (IL-8) expression.

The GABAB Receptor Mediates Neuroprotection by Coupling to G13

[Science Signaling] Scientists found that GABABR phosphorylated the kinase JNK downstream of activation of the small guanosine triphosphatases RhoA and Rac1 in primary mouse neurons.

Costimulation Molecules Differentially Regulate the ERK-Zfp831 Axis to Shape T Follicular Helper Cell Differentiation

[Immunity] The authors found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.

SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages

[Cell Reports] The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.

The RhoA Dependent Anti-Metastatic Function of RKIP in Breast Cancer

[Scientific Reports] Researchers showed that RKIP inhibited cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activated RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression.

RNA-Seq of Human T Cells after Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Regulator of T Cell Alloimmunity

[Science Translational Medicine] Linc00402 was increased in donor T cells from patients who underwent allogeneic cardiac transplantation and in murine T cells.

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