Tag results:
ERK2
Dermal Cell News
Tpl2 Contributes to IL-1β-Induced IL-8 Expression via ERK1/2 Activation in Canine Dermal Fibroblasts
[PLoS One] Investigators established a model for interleukin 1β (IL-1β)-induced dermatitis and investigated mitogen-activated protein kinase signaling pathways in IL-1β-induced interleukin 8 (IL-8) expression.
Neural Cell News
The GABAB Receptor Mediates Neuroprotection by Coupling to G13
[Science Signaling] Scientists found that GABABR phosphorylated the kinase JNK downstream of activation of the small guanosine triphosphatases RhoA and Rac1 in primary mouse neurons.
Human Immunology News
Costimulation Molecules Differentially Regulate the ERK-Zfp831 Axis to Shape T Follicular Helper Cell Differentiation
[Immunity] The authors found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.
Immune Regulation News
SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages
[Cell Reports] The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.
Mammary Cell News
The RhoA Dependent Anti-Metastatic Function of RKIP in Breast Cancer
[Scientific Reports] Researchers showed that RKIP inhibited cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activated RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression.
Cell Therapy News
RNA-Seq of Human T Cells after Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Regulator of T Cell Alloimmunity
[Science Translational Medicine] Linc00402 was increased in donor T cells from patients who underwent allogeneic cardiac transplantation and in murine T cells.