The authors found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Researchers showed that RKIP inhibited cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activated RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression.
[zotpress userid=’7992332′ items=’BEJ8GG2K’ style=’apa’ cite=’yes’]
Linc00402 was increased in donor T cells from patients who underwent allogeneic cardiac transplantation and in murine T cells.
[Science Translational Medicine]
[zotpress userid=’6445218′ items=’2GPRFIJM’ style=’apa’ cite=’yes’]
Investigators demonstrated that ERK2 drove BRAF-mutant melanoma gene expression and proliferation as a function of its higher expression compared to ERK1.
[Molecular Cancer Research]
[zotpress userid=’6606345′ items=’I9YI5PT4′ style=’apa’ cite=’yes’]
Researchers showed that ULK1 deficiency induced an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis.
[zotpress userid=’6807162′ items=’KW32PGC2′ style=’apa’ cite=’yes’]
Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche.
[zotpress userid=’6606345′ items=’4CZGU26Z’ style=’apa’ cite=’yes’]
This study showed that exit from the stem cell compartment in mammalian epidermis was characterized by pulsatile ERK MAPK activity.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=’6606345′ items=’M24T75TY’ style=’apa’ cite=’yes’]