Costimulation Molecules Differentially Regulate the ERK-Zfp831 Axis to Shape T Follicular Helper Cell Differentiation

The authors found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.
[Immunity]
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SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages

The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.
[Cell Reports]
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The RhoA Dependent Anti-Metastatic Function of RKIP in Breast Cancer

Researchers showed that RKIP inhibited cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activated RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression.
[Scientific Reports]
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RNA-Seq of Human T Cells after Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Regulator of T Cell Alloimmunity

Linc00402 was increased in donor T cells from patients who underwent allogeneic cardiac transplantation and in murine T cells.
[Science Translational Medicine]
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RAF-Mutant Melanomas Differentially Depend on ERK2 over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

Investigators demonstrated that ERK2 drove BRAF-mutant melanoma gene expression and proliferation as a function of its higher expression compared to ERK1.
[Molecular Cancer Research]
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MAPK1/3 Kinase-Dependent ULK1 Degradation Attenuates Mitophagy and Promotes Breast Cancer Bone Metastasis

Researchers showed that ULK1 deficiency induced an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis.
[Autophagy]
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Targeting Disseminated Estrogen-Receptor-Positive Breast Cancer Cells in Bone Marrow

Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche.
[Oncogene]
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Regulation of ERK Basal and Pulsatile Activity Control Proliferation and Exit from the Stem Cell Compartment in Mammalian Epidermis

This study showed that exit from the stem cell compartment in mammalian epidermis was characterized by pulsatile ERK MAPK activity.
[Proceedings of the National Academy of Sciences of the United States of America]
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