MAPK1/3 Kinase-Dependent ULK1 Degradation Attenuates Mitophagy and Promotes Breast Cancer Bone Metastasis

Researchers showed that ULK1 deficiency induced an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis.
[Autophagy]
Deng, R., Zhang, H.-L., Huang, J.-H., Cai, R.-Z., Wang, Y., Chen, Y.-H., Hu, B.-X., Ye, Z.-P., Li, Z.-L., Mai, J., Huang, Y., Li, X., Peng, X.-D., Feng, G.-K., Li, J.-D., Tang, J., & Zhu, X.-F. (2020). MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1850609 Cite
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Targeting Disseminated Estrogen-Receptor-Positive Breast Cancer Cells in Bone Marrow

Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche.
[Oncogene]
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Regulation of ERK Basal and Pulsatile Activity Control Proliferation and Exit from the Stem Cell Compartment in Mammalian Epidermis

This study showed that exit from the stem cell compartment in mammalian epidermis was characterized by pulsatile ERK MAPK activity.
[Proceedings of the National Academy of Sciences of the United States of America]
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