Isolation and Characterisation of Lymphatic Endothelial Cells from Lung Tissues Affected by Lymphangioleiomyomatosis

Researchers found that lymphangioleiomyomatosi – affected lung tissues (LAM-LECs) had significantly higher ability of proliferation and migration compared to control LECs.
[Scientific Reports]
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Isolation and Characterisation of Lymphatic Endothelial Cells from Lung Tissues Affected by Lymphangioleiomyomatosis

Hhuman primary-cultured lymphatic endothelial cells were obtained both from lymphangioleiomyomatosis-affected lung tissues and normal lung tissues using fluorescence-activated cell sorting.
[Scientific Reports]
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Adhesion Receptor Adgrg2/Gpr64 Is In The Gi-Tract Selectively Expressed In Mature Intestinal Tuft Cells

Time-lapse studies of organoids from Trpm5GFP:Gpr64mCherry mice revealed sequential expression of initially Trpm5GFP and subsequently also Gpr64mCherry in maturing intestinal tuft cells.
[Molecular Metabolism]
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BCL3 Couples Cancer Stem Cell Enrichment with Pancreatic Cancer Molecular Subtypes

Scientists demonstrated that Bcl3 impacted pancreatic carcinogenesis by restraining cancer stem cell expansion and by curtailing an aggressive and metastatic tumor burden in pancreatic ductal adenocarcinoma across species.
[Gastroenterology]
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Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Crest Cells for Corneal Endothelial Regeneration

Transplantation of the hiPSC-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
[Stem Cell Research & Therapy]
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AP-2alpha Regulates S-Phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer

CRISPR-Cas9 and shRNA were used to eliminate TFAP2A expression in HCT116 and a panel of colon cancer cell lines.
[Molecular Cancer Research]
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Single Cell RNA-Sequencing Uncovers Paracrine Functions of the Epicardial-Derived Cells in Arrhythmogenic Cardiomyopathy

Epicardial-derived cardiac fibroblasts and epithelial cells express paracrine factors, including TGFβ1 and FGFs, which mediate EMT, and contribute to the pathogenesis of myocardial fibrosis, apoptosis, arrhythmias, and cardiac dysfunction in a mouse model of arrhythmogenic cardiomyopathy.
[Circulation]
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Cardiovascular Disease Risk Factors Induce Mesenchymal Features and Senescence in Mouse Cardiac Endothelial Cells

Scientists applied florescence-activated cell sorting, RNA sequencing and bioinformatic methods to investigate the common effects of cardiovascular disease risk factors in mouse cardiac endothelial cells.
[eLife]
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BMP4 Overexpression Induces the Upregulation of APP/Tau and Memory Deficits in Alzheimer’s Disease

In multiple cell lines, the overexpression of BMP4 increased the expression of Alzheimer’s disease-related proteins, whereas the downregulation of BMP4 demonstrated opposing effects.
[Cell Death Discovery]
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Human BM-MSC Secretome Enhances Human Granulosa Cell Proliferation and Steroidogenesis and Restores Ovarian Function in Primary Ovarian Insufficiency Mouse Model

The authors report that the human mesenchymal stem cell (hMSC) secretome increased the proliferation of human granulosa cells (HGrC1). They showed by FACS analysis that treatment of HGrC1 cells with hMSC-conditioned media stimulated cellular proliferation.
[Scientific Reports]
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Phage Display Screening Identifies a Prostate Specific Antigen (PSA)–/Lo Prostate Cancer Cell Specific Peptide to Retard Castration Resistance of Prostate Cancer

Prostate-specific antigen (PSA)+ and PSA−/lo cells were successfully separated from LNCaP xenograft tumors after prostate- PSAP-GFP vector infection and FACS.
[Translational Oncology]
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