FACS

[International Journal of Oncology] The authors evaluated the effects of tumor‑treating fields with different duty cycles on glioma spheroid cells and normal brain organoids.

[Journal of Hepatology] Investigators undertook molecular and functional studies to interrogate the significance of the myeloid Ikaros–SIRT1 axis in the innate immune activation and to determine whether it served as a homeostatic sentinel in hepatic rejuvenation in mouse and human liver.

[American Journal of Physiology-Cell Physiology] Scientists generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs.

[Laboratory Investigation] Scientists investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.

[Frontiers in Cell and Developmental Biology] Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.

[Stem Cell Reviews and Reports] For the purpose of easy monitoring of differentiation efficiencies into pancreatic progenitors and insulin-producing cells, scientists generated new reporter lines by knocking in a P2A-H-2Kk-F2A-GFP2 reporter gene into the SOX9-locus and a P2A-mCherry reporter gene into the INS-locus mediated by CRISPR/CAS9-technology.