Antileukemic Activity of the VPS34-IN1 Inhibitor in Acute Myeloid Leukemia

Using a recently developed specific inhibitor, the authors found that vacuolar protein sorting 34 inhibition induces apoptosis in acute myeloid leukemia cells but not in normal CD34+ hematopoietic cells.
[Oncogenesis]
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Preclinical Evaluation of a Regimen Combining Chidamide and ABT-199 in Acute Myeloid Leukemia

Scientists reported that a newly emerged histone deacetylase inhibitor, chidamide, at low-cytotoxicity dose enhanced the anti-AML activity of ABT-199, while sparing normal hematopoietic progenitor cells.
[Cell Death & Disease]
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All-Trans Retinoic Acid in Non-Promyelocytic Acute Myeloid Leukemia: Driver Lesion Dependent Effects on Leukemic Stem Cells

The author summarizes the role of all-trans retinoic acidin normal hematopoiesis and in cute amyeloid leukemia (AML), focusing on its impact on AML stem cells.
[Cell Cycle]
Nguyen, C. H., Grandits, A. M., Purton, L. E., Sill, H., & Wieser, R. (2020). All-trans retinoic acid in non-promyelocytic acute myeloid leukemia: driver lesion dependent effects on leukemic stem cells. Cell Cycle, 0(0), 1–16. https://doi.org/10.1080/15384101.2020.1810402 Cite
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All-Trans Retinoic Acid in Non-Promyelocytic Acute Myeloid Leukemia: Driver Lesion Dependent Effects on Leukemic Stem Cells

This authors summarize the role of all-trans retinoic acid in normal hematopoiesis and in acute myeloid leukemia (AML), focusing on its impact on AML stem cells.
[Cell Cycle]
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Characterization of FLT3-ITDmut Acute Myeloid Leukemia: Molecular Profiling of Leukemic Precursor Cells

Investigators characterized the distribution of FLT3-ITD mutation in different progenitor cell subsets to shed light on the subclonal architecture of FLT3-ITDmut acute myeloid leukemia.
[Blood Cancer Journal]
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Prognostic Impact of TP53 Mutation, Monosomal Karyotype, and Prior Myeloid Disorder in Nonremission Acute Myeloid Leukemia at allo-HSCT

Researchers analyzed prognostic gene mutations by targeted next-generation sequencing to identify predisposing factors for predicting overall survival at one month before transplantation. They enrolled 120 patients with nonremission acute myeloid leukemia who underwent first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2005 and 2018.
[Bone Marrow Transplantation]
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