Induction of Cancer Cell Stemness in Glioma through Glycolysis and the Long Noncoding RNA HULC-Activated FOXM1/AGR2/HIF-1α Axis

Brain tissues were clinically collected from 50 patients with glioblastoma and 35 patients with acute craniocerebral injury, followed by immunohistochemical detection of the expression patterns of Forkhead box M1, anterior gradient 2, and hypoxia-inducible factor-1α.
[Laboratory Investigation]
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Distinct Roles of KLF4 in Mesenchymal Cell Subtypes during Lung Fibrogenesis

Researchers indicated that KLF4 played opposing roles in platelet-derived growth factor receptor-β+ cells and α-smooth muscle actin+ cells and highlighted the importance of further studies of interactions between distinct mesenchymal cell types.
[Nature Communications]
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FOXM1 Accelerates Wound Healing in Diabetic Foot Ulcer by Inducing M2 Macrophage Polarization through a Mechanism Involving SEMA3C/NRP2/Hedgehog Signaling

Scientists illustrated the molecular mechanisms by which Forkhead box M1 (FOXM1) enhanced M2 polarization and wound healing of diabetic foot ulcer.
[Diabetes Research and Clinical Practice]
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PRMT7 Targets of Foxm1 Controls Alveolar Myofibroblast Proliferation and Differentiation during Alveologenesis

Scientists provide evidence for PRMT7’s function in regulating alveolar myofibroblasts proliferation and differentiation during lung alveologenesis.
[Cell Death & Disease]
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Dysregulation of miR-23b-5p Promotes Cell Proliferation via Targeting FOXM1 in Hepatocellular Carcinoma

Gain- or loss-of-function assays demonstrated that miR-23b-5p induced G0/G1 cell cycle arrest and inhibited cell proliferation both in vitro and in vivo. qRT-PCR, western blot and luciferase assays verified that Mammalian transcription factor Forkhead Box M1 (FOXM1), upregulated in hepatocellular carcinoma specimens, was negatively correlated with miR-23b-5p expression and acted as a direct downstream target of miR-23b-5p.
[Cell Death Discovery]
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BKM120 Sensitizes BRCA-Proficient Triple Negative Breast Cancer Cells to Olaparib through Regulating FOXM1 and Exo1 Expression

Scientists found that dual phosphoinositide 3-kinase (PI3K) and poly (ADP-ribose) polymerase inhibition with BKM120 and olaparib significantly reduced the proliferation of BRCA-proficient TNBC cell lines.
[Scientific Reports]
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Chronic Exposure to Microcystin-LR Increases the Risk of Prostate Cancer and Induces Malignant Transformation of Human Prostate Epithelial Cells

In vitro, over 25 weeks of microcystins-LR exposure, normal human prostate epithelial (RWPE-1) cells increased secretion of matrix metalloproteinase-2, matrix metalloproteinase-9, and colony formation, features typical for cancer cells.
[Chemosphere]
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