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Forkhead box M1

Dinaciclib Inhibits the Stemness of Two Subtypes of Human Breast Cancer Cells by Targeting the FoxM1 and Hedgehog Signaling Pathway

[Oncology Reports] Investigators aimed to examine the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.

Induction of Cancer Cell Stemness in Glioma through Glycolysis and the Long Noncoding RNA HULC-Activated FOXM1/AGR2/HIF-1α Axis

[Laboratory Investigation] Brain tissues were clinically collected from 50 patients with glioblastoma and 35 patients with acute craniocerebral injury, followed by immunohistochemical detection of the expression patterns of Forkhead box M1, anterior gradient 2, and hypoxia-inducible factor-1α.

Distinct Roles of KLF4 in Mesenchymal Cell Subtypes during Lung Fibrogenesis

[Nature Communications] Researchers indicated that KLF4 played opposing roles in platelet-derived growth factor receptor-β+ cells and α-smooth muscle actin+ cells and highlighted the importance of further studies of interactions between distinct mesenchymal cell types.

FOXM1 Accelerates Wound Healing in Diabetic Foot Ulcer by Inducing M2 Macrophage Polarization through a Mechanism Involving SEMA3C/NRP2/Hedgehog Signaling

[Diabetes Research and Clinical Practice] Scientists illustrated the molecular mechanisms by which Forkhead box M1 (FOXM1) enhanced M2 polarization and wound healing of diabetic foot ulcer.

PRMT7 Targets of Foxm1 Controls Alveolar Myofibroblast Proliferation and Differentiation during Alveologenesis

[Cell Death & Disease] Scientists provide evidence for PRMT7’s function in regulating alveolar myofibroblasts proliferation and differentiation during lung alveologenesis.

Dysregulation of miR-23b-5p Promotes Cell Proliferation via Targeting FOXM1 in Hepatocellular Carcinoma

[Cell Death Discovery] Gain- or loss-of-function assays demonstrated that miR-23b-5p induced G0/G1 cell cycle arrest and inhibited cell proliferation both in vitro and in vivo. qRT-PCR, western blot and luciferase assays verified that Mammalian transcription factor Forkhead Box M1 (FOXM1), upregulated in hepatocellular carcinoma specimens, was negatively correlated with miR-23b-5p expression and acted as a direct downstream target of miR-23b-5p.

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