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GABAergic

Electrophysiological- and Neuropharmacological-Based Benchmarking of Human Induced Pluripotent Stem Cell-Derived and Primary Rodent Neurons

[Stem Cell Reviews and Reports] Scientists differentiated human amniotic fluid-derived iPSCs into a mixed population of neurons. Functional assessments were performed by evaluating electrophysiological properties and the effect of a panel of neuropharmacological agents on spontaneous activity.

Induction of Inverted Morphology in Brain Organoids by Vertical-Mixing Bioreactors

[Communications Biology] The authors examined the vertical-mixing effect on brain organoid structures using bioreactors and established inverted brain organoids.

Neurotransmitter Signaling Regulates Distinct Phases of Multimodal Human Interneuron Migration

[EMBO Journal] Scientists used cerebral organoids to identify key roles of neurotransmitter signaling pathways in guiding the migratory behavior of human cortical interneurons.

Neuronal Excitatory-to-Inhibitory Balance Is Altered in Cerebral Organoid Models of Genetic Neurological Diseases

[Molecular Brain] Scientists utilized no known disease/healthy cerebral organoids (COs) as normal function controls. At 3–4 and 6–10 months post-differentiation, COs with mutations showed no evidence of disease-related pathology.

Recruitment and Inhibitory Action of Hippocampal Axo-Axonic Cells during Behavior

[Neuron] Scientists achieved cell-type-specific genetic access to axo-axonic cells (AACs) in mice and showed that AACs in the hippocampal area CA1 were synchronously activated by episodes of locomotion or whisking during rest.

Kainate Receptors Regulate the Functional Properties of Young Adult-Born Dentate Granule Cells

[Cell Reports] Researchers demonstrated that glutamate receptors of the kainate receptor subfamily were expressed in adult-born dentate granule cells and that, through their interaction with GABAergic signaling mechanisms, they altered the functional properties of adult-born cells during a critical period of their development.

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