Therapeutic Benefit of Muse Cells in a Mouse Model of Amyotrophic Lateral Sclerosis

Researchers suggested that Muse cells homed in a lesion site-dependent manner and protected the spinal cord against motor neuron death. Muse cells might also be a promising cell source for the treatment of amyotrophic lateral sclerosis patients.
[Scientific Reports]
Yamashita, T., Kushida, Y., Wakao, S., Tadokoro, K., Nomura, E., Omote, Y., Takemoto, M., Hishikawa, N., Ohta, Y., Dezawa, M., & Abe, K. (2020). Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. Scientific Reports, 10(1), 17102. https://doi.org/10.1038/s41598-020-74216-4 Cite
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EGFR/FOXO3a/BIM Signaling Pathway Determines Chemosensitivity of BMP4-Differentiated Glioma Stem Cells to Temozolomide

Scientists examined whether epidermal growth factor receptor (EGFR) signaling affects bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]
Ciechomska, I. A., Gielniewski, B., Wojtas, B., Kaminska, B., & Mieczkowski, J. (2020). EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-0479-9 Cite
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Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats

Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
[Neuroscience Research]
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