The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma

Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
[Cell Death & Disease]
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Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Facilitate the Repair of Spinal Cord Injury via the miR-29b-3p/PTEN/Akt/mTOR Axis

Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.
[Cell Death Discovery]
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Exposure to Cadmium Induces Neuroinflammation and Impairs Ciliogenesis in hESC-Derived 3D Cerebral Organoids

The authors identified that cadmium exposure specifically induced apoptosis in neurons and inhibited the proliferation of neural progenitor cells, but neural differentiation was not significantly affected in cerebral organoids.
[Science of the Total Environment]
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ISL1 Promoted Tumorigenesis and EMT via Aurora Kinase A-Induced Activation of PI3K/AKT Signaling Pathway in Neuroblastoma

Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 is preferentially upregulated in NB tissues compared with normal tissues.
[Cell Death & Disease]
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Experimental Autoimmune Encephalomyelitis via Regulating Pro and Anti-Inflammatory Cytokines

Scientists investigated the effect of extracellular vesicles derived from human umbilical cord-MSC on the clinical score and inflammatory/anti-inflammatory cytokines on the EAE mouse model.
[Scientific Reports]
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Ndufs4 Ablation Decreases Synaptophysin Expression in Hippocampus

Researchers silenced Ndufs4 in Neuro-2a cells and we observed shorter neurite lengths with decreased expression of synaptophysin.
[Scientific Reports]
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Novel Fragile X Syndrome 2D and 3D Brain Models Based on Human Isogenic FMRP-KO iPSCs

Scientists generated 2D and 3D in vitro human FXS model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines.
[Cell Death & Disease]
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Matrix Stiffness Changes Affect Astrocyte Phenotype in an In Vitro Injury Model

Researchers established an in vitro model to assess the responses of astrocytes to matrix stiffness changes that may be related to pathophysiology.
[NPG Asia Materials]
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Astrocytic Atrophy as a Pathological Feature of Parkinson’s Disease with LRRK2 Mutation

In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.
[npj Parkinsons Disease]
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GFAP Hyperpalmitoylation Exacerbates Astrogliosis and Neurodegenerative Pathology in PPT1-Deficient Mice

Researchers showed that glial fibrillary acidic protein (GFAP) was readily palmitoylated in vitro and in vivo; specifically, cysteine-291 was the unique palmitoylated residue in GFAP.
[Proceedings of the National Academy of Sciences of the United States of America]
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Gli2-Regulated Activation of Hepatic Stellate Cells and Liver Fibrosis by TGF-β Signaling

Scientists investigated the effect of Gli2 on liver fibrogenesis and its possible mechanism using conditional knockout Gli2 mice and hepatic stellate cell models.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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