Identification and Functional Characterization of CD133+GFAP+CD117+Sca1+ Neural Stem Cells

C57BL/6 mice were used to isolate and identify CD133+GFAP+CD117+Sca1+ cells in the hippocampal dentate gyrus region of the mouse brain as a novel neural stem cell population, in terms of cell phenotype, self-renewal capacity, and differentiation capability.
[Molecular and Cellular Biochemistry]
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GFAP Splice Variants Fine-Tune Glioma Cell Invasion and Tumor Dynamics by Modulating Migration Persistence

The authors showed that the glial fibrillary acidic protein δ (GFAPδ) and GFAPα isoforms differentially regulated the tumor dynamics of glioma cells. Depletion of either isoform increased the migratory capacity of glioma cells.
[Scientific Reports]
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Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model

Investigators manufactured neprilysin gene-enhanced human umbilical cord-derived MSCs and intravenously transplanted them in Aβ1-42-injected Alzheimer’s disease animal models.
[Stem Cells International]
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Enteric Glial Cell Heterogeneity Regulates Intestinal Stem Cell Niches

Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.
[Cell Stem Cell]
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The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma

Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
[Cell Death & Disease]
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Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Facilitate the Repair of Spinal Cord Injury via the miR-29b-3p/PTEN/Akt/mTOR Axis

Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.
[Cell Death Discovery]
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Exposure to Cadmium Induces Neuroinflammation and Impairs Ciliogenesis in hESC-Derived 3D Cerebral Organoids

The authors identified that cadmium exposure specifically induced apoptosis in neurons and inhibited the proliferation of neural progenitor cells, but neural differentiation was not significantly affected in cerebral organoids.
[Science of the Total Environment]
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ISL1 Promoted Tumorigenesis and EMT via Aurora Kinase A-Induced Activation of PI3K/AKT Signaling Pathway in Neuroblastoma

Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 is preferentially upregulated in NB tissues compared with normal tissues.
[Cell Death & Disease]
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Experimental Autoimmune Encephalomyelitis via Regulating Pro and Anti-Inflammatory Cytokines

Scientists investigated the effect of extracellular vesicles derived from human umbilical cord-MSC on the clinical score and inflammatory/anti-inflammatory cytokines on the EAE mouse model.
[Scientific Reports]
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Ndufs4 Ablation Decreases Synaptophysin Expression in Hippocampus

Researchers silenced Ndufs4 in Neuro-2a cells and we observed shorter neurite lengths with decreased expression of synaptophysin.
[Scientific Reports]
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Novel Fragile X Syndrome 2D and 3D Brain Models Based on Human Isogenic FMRP-KO iPSCs

Scientists generated 2D and 3D in vitro human FXS model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines.
[Cell Death & Disease]
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