GLI1

[Stem Cells and Development] Researchers established patient derived glioblastoma stem cells (GSCs), determined cancer stem cell marker expression, and immunostained GSCs to assess cell viability and apoptosis.

[Toxicology Letters] Small intestinal organoids were used to assess if arsenic exposure would also impair intestinal stem cell differentiation. No changes in markers of differentiated epithelial cells were seen.

[Bone Research] Expression and lineage analysis showed selective expression of discoidin domain receptor 2 (Ddr2) at early stages of bone formation in the resting zone and proliferating chondrocytes and periosteum.

[Cancer Biotherapy and Radiopharmaceuticals] Researchers analyzed the correlation between Sonic Hedgehog or Gli1 and osteopontin expression in human pancreatic ductal adenocarcinoma. They also evaluated the proliferation, apoptosis, migration, and invasion of Gli1-knockdown BxPC-3 cells.

[Molecular Cancer] CircIPO11 was highly expressed in hepatocellular carcinoma (HCC) tumor tissues and liver cancer stem cells (CSCs), and was required for the self-renewal maintenance of liver CSCs to initiate HCC development.

[Development] Researchers demonstrated that selective deletion of stromal androgen-receptor expression in prepubescent Shh responsive Gli1-expressing cells significantly impeded pubertal prostate epithelial growth and development.