Investigators investigated the inhibitory effect of miR‑367‑3p on the proliferation, invasion, and metastasis of prostate cancer cells.
6445212 LZD9YS7K items 1 apa default asc 1
The pathogenic mechanisms underlying joint dysfunction in osteogenesis imperfecta are poorly understood. The authors generated a mouse model in which Fkbp10 was conditionally deleted in tendons and ligaments.
[Proceedings of the National Academy of Sciences of the United States of America]
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Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.
[Cell Death Discovery]
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Researchers indicated that a high level of glucose exposure does not effect the invasion and migration of PANC-1 cells, while aspartame increases both of these aggressiveness criterias.
[Food and Chemical Toxicology]
Researchers identified a novel SOX2-BRD4 transcriptional complex driving the expression of GLI1, the final effector of the Hedgehog/GLI (HH/GLI) pathway, providing a novel mechanism of non-canonical Smoothened-independent activation of HH/GLI signaling in melanoma.
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Pietrobono, S., Gaudio, E., Gagliardi, S., Zitani, M., Carrassa, L., Migliorini, F., Petricci, E., Manetti, F., Makukhin, N., Bond, A. G., Paradise, B. D., Ciulli, A., Fernandez-Zapico, M. E., Bertoni, F., & Stecca, B. (2021). Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01783-9 Cite
Scientists assessed the expression of key genes involved in hedgehog signaling in prostate cancer and investigated the potential role of smoothened in the pathogenesis of neuroendocrine prostate cancer.
6445212 3LWSD7WS items 1 apa default asc 1
Investigators found that mesenchymal stem cell CD47 and macrophage signal regulatory protein alpha expression were increased after LPS stimulation.
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Investigators found that GPR126 had higher expression in most colorectal cancer cell lines than in normal colon epithelial cell lines, and higher expression levels in colorectal cancer tissues than in normal adjacent colon tissues.
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Using a lineage tracing mouse model, the authors demonstrated that Gli1 marks a small subset of muscle‐resident fibro‐adipogenic progenitors with elevated Hedgehog signaling.
[Journal of Bone and Mineral Research]
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Yao, L., Tichy, E. D., Zhong, L., Mohanty, S., Wang, L., Ai, E., Yang, S., Mourkioti, F., & Qin, L. (n.d.). Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. Journal of Bone and Mineral Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jbmr.4265 Cite
Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
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The authors found that chemotherapy exacerbated the migration and CSC-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition markers Vimentin and Snail.
[European Journal of Pharmacology]
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Zhao, Y., Yang, X., Zhao, J., Gao, M., Zhang, M., Shi, T., Zhang, F., Zheng, X., Pan, Y., Shao, D., Li, J., He, K., & Chen, L. (2021). Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1. European Journal of Pharmacology, 895, 173887. https://doi.org/10.1016/j.ejphar.2021.173887 Cite