MiR-367-3p Downregulates Rab23 Expression and Inhibits Hedgehog Signaling Resulting in the Inhibition of the Proliferation, Migration, and Invasion of Prostate Cancer Cells

Investigators investigated the inhibitory effect of miR‑367‑3p on the proliferation, invasion, and metastasis of prostate cancer cells.
[Oncology Reports]
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Localized Chondro-Ossification Underlies Joint Dysfunction and Motor Deficits in the Fkbp10 Mouse Model of Osteogenesis Imperfecta

The pathogenic mechanisms underlying joint dysfunction in osteogenesis imperfecta are poorly understood. The authors generated a mouse model in which Fkbp10 was conditionally deleted in tendons and ligaments.
[Proceedings of the National Academy of Sciences of the United States of America]
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ETV4 Promotes Breast Cancer Cell Stemness by Activating Glycolysis and CXCR4-Mediated Sonic Hedgehog Signaling

Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.
[Cell Death Discovery]
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Aspartame Induces Cancer Stem Cell Enrichment through p21, NICD and GLI1 in Human PANC-1 Pancreas Adenocarcinoma Cells

Researchers indicated that a high level of glucose exposure does not effect the invasion and migration of PANC-1 cells, while aspartame increases both of these aggressiveness criterias.
[Food and Chemical Toxicology]
Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells. (2021). Food and Chemical Toxicology, 112264. https://doi.org/10.1016/j.fct.2021.112264 Cite
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Targeting Non-Canonical Activation of GLI1 by the SOX2-BRD4 Transcriptional Complex Improves the Efficacy of HEDGEHOG Pathway Inhibition in Melanoma

Researchers identified a novel SOX2-BRD4 transcriptional complex driving the expression of GLI1, the final effector of the Hedgehog/GLI (HH/GLI) pathway, providing a novel mechanism of non-canonical Smoothened-independent activation of HH/GLI signaling in melanoma.
[Oncogene]
Pietrobono, S., Gaudio, E., Gagliardi, S., Zitani, M., Carrassa, L., Migliorini, F., Petricci, E., Manetti, F., Makukhin, N., Bond, A. G., Paradise, B. D., Ciulli, A., Fernandez-Zapico, M. E., Bertoni, F., & Stecca, B. (2021). Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01783-9 Cite
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Smoothened Loss Is a Characteristic of Neuroendocrine Prostate Cancer

Scientists assessed the expression of key genes involved in hedgehog signaling in prostate cancer and investigated the potential role of smoothened in the pathogenesis of neuroendocrine prostate cancer.
[Prostate]
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CD47-Mediated Hedgehog/SMO/GLI1 Signaling Promotes Mesenchymal Stem Cell Immunomodulation in Mouse Liver Inflammation

Investigators found that mesenchymal stem cell CD47 and macrophage signal regulatory protein alpha expression were increased after LPS stimulation.
[Hepatology]
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GPR126 Regulates Colorectal Cancer Cell Proliferation by Mediating HDAC2 and GLI2 Expression

Investigators found that GPR126 had higher expression in most colorectal cancer cell lines than in normal colon epithelial cell lines, and higher expression levels in colorectal cancer tissues than in normal adjacent colon tissues.
[Cancer Science]
Cui, H., Yu, W., Yu, M., Luo, Y., Yang, M., Cong, R., Chu, X., Gao, G., & Zhong, M. (n.d.). GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression. Cancer Science, n/a(n/a). https://doi.org/https://doi.org/10.1111/cas.14868 Cite
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Gli1 Defines a Subset of Fibroadipogenic Progenitors that Promote Skeletal Muscle Regeneration with Less Fat Accumulation

Using a lineage tracing mouse model, the authors demonstrated that Gli1 marks a small subset of muscle‐resident fibro‐adipogenic progenitors with elevated Hedgehog signaling.
[Journal of Bone and Mineral Research]
Yao, L., Tichy, E. D., Zhong, L., Mohanty, S., Wang, L., Ai, E., Yang, S., Mourkioti, F., & Qin, L. (n.d.). Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. Journal of Bone and Mineral Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jbmr.4265 Cite
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Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
[Cancers]
Lu, Y., Zhu, Y., Deng, S., Chen, Y., Li, W., Sun, J., & Xu, X. (2021). Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth. Cancers, 13(3), 418. https://doi.org/10.3390/cancers13030418 Cite
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Berberine Inhibits Chemotherapy-Exacerbated Ovarian Cancer Stem Cell-Like Characteristics and Metastasis through GLI1

The authors found that chemotherapy exacerbated the migration and CSC-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition markers Vimentin and Snail.
[European Journal of Pharmacology]
Zhao, Y., Yang, X., Zhao, J., Gao, M., Zhang, M., Shi, T., Zhang, F., Zheng, X., Pan, Y., Shao, D., Li, J., He, K., & Chen, L. (2021). Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1. European Journal of Pharmacology, 895, 173887. https://doi.org/10.1016/j.ejphar.2021.173887 Cite
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