GLI1

[Cell Death & Disease] ENC1-SEdistal deletion reduced ENC1 expression and inhibited the malignant behavior of breast carcinoma cells and their resistance to radiotherapy.

[Oncology Reports] Investigators investigated the inhibitory effect of miR‑367‑3p on the proliferation, invasion, and metastasis of prostate cancer cells.

[Proceedings of the National Academy of Sciences of the United States of America] The pathogenic mechanisms underlying joint dysfunction in osteogenesis imperfecta are poorly understood. The authors generated a mouse model in which Fkbp10 was conditionally deleted in tendons and ligaments.

[Cell Death Discovery] Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.

[Food and Chemical Toxicology] Researchers indicated that a high level of glucose exposure does not effect the invasion and migration of PANC-1 cells, while aspartame increases both of these aggressiveness criterias.

[Oncogene] Researchers identified a novel SOX2-BRD4 transcriptional complex driving the expression of GLI1, the final effector of the Hedgehog/GLI (HH/GLI) pathway, providing a novel mechanism of non-canonical Smoothened-independent activation of HH/GLI signaling in melanoma.