GLI1

[Prostate] Scientists assessed the expression of key genes involved in hedgehog signaling in prostate cancer and investigated the potential role of smoothened in the pathogenesis of neuroendocrine prostate cancer.

[Hepatology] Investigators found that mesenchymal stem cell CD47 and macrophage signal regulatory protein alpha expression were increased after LPS stimulation.

[Cancer Science] Investigators found that GPR126 had higher expression in most colorectal cancer cell lines than in normal colon epithelial cell lines, and higher expression levels in colorectal cancer tissues than in normal adjacent colon tissues.

[Journal of Bone and Mineral Research] Using a lineage tracing mouse model, the authors demonstrated that Gli1 marks a small subset of muscle‐resident fibro‐adipogenic progenitors with elevated Hedgehog signaling.

[Cancers] Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.

[European Journal of Pharmacology] The authors found that chemotherapy exacerbated the migration and CSC-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition markers Vimentin and Snail.