GWAS

[Cell Genomics] Investigators mapped genetic regulation of gene expression and chromatin activity in regulatory T cells and identified 133 colocalizing loci with immune disease variants.

[Cell Proliferation] Scientists recapitulated the time course of fetal skeletal muscle development in vitro and explored the dynamic changes of chromatin accessibility and gene expression during bovine myoblasts proliferation and differentiation.

[American Journal of Respiratory Cell and Molecular Biology] To assess methylation profiles in the main COPD target organ, investigators performed an epigenome-wide association study on bronchoalveolar lavage cells.

[cell genomics] Applying single-cell transposome hypersensitive site sequencing to over 80,000 cells, researchers assembled the first regulatory atlas of postnatal human and mouse lung alveolar development.

[Genome Medicine] Researchers found that 34 risk genes were significantly associated with severe COVID-19, and the number of highly expressed genes increased with the severity of COVID-19.

[Signal Transduction and Targeted Therapy] Scientists identified two 4q12 long noncoding RNAs LCETRL3 and LCETRL4 which could significantly dimmish EGFR-TKIs efficiency.