KARATE: PKA-Induced KRAS4B-RHOA-mTORC2 Supercomplex Phosphorylates AKT in Insulin Signaling and Glucose Homeostasis

By investigating insulin receptor signaling in human cells and biochemical reconstitution, scientists found that insulin induced the activation of mTORC2 toward AKT by assembling a supercomplex with KRAS4B and RHOA GTPases, termed KARATE (KRAS4B-RHOA-mTORC2 Ensemble).
[Molecular Cell]
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The Promise(s) of Mesenchymal Stem Cell Therapy in Averting Preclinical Diabetes: Lessons from In Vivo and In Vitro Model Systems

Investigators showed that intramuscular injection of placental (P)-MSCs homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.
[Scientific Reports]
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A Xanthene Derivative, DS20060511, Attenuates Glucose Intolerance by Inducing Skeletal Muscle-Specific GLUT4 Translocation in Mice

Scientists showed a xanthene derivative, DS20060511, induced GLUT4 translocation to the skeletal muscle cell surface, thereby stimulating glucose uptake into the tissue.
[Communications Biology]
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Integrated Analysis of Long Non-Coding RNAs and mRNAs Associated with Malignant Transformation of Gastrointestinal Stromal Tumors

The authors revealed a series of key pathways and hub long non-coding RNAs involved in the malignant transformation of gastrointestinal stromal tumors (GISTs). DNM3OS promoted GIST cell proliferation and mitosis by regulating the expression of GLUT4 and CD36.
[Cell Death & Disease]
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Beta-Catenin Is Required for Optimal Exercise and Contraction Stimulated Skeletal Muscle Glucose Uptake

Muscle specific deletion of β-catenin induced in adult mice impaired both exercise and contraction (isolated muscle) induced glucose uptake without affecting running performance or canonical exercise signaling pathways.
[Journal of Physiology]
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Linking Metabolic Dysfunction with Cardiovascular Diseases: Brn-3b/POU4F2 Transcription Factor in Cardiometabolic Tissues in Health and Disease

Scientists explore the emerging evidence that supports novel and important roles for the POU4F2/Brn-3b transcription factor in controlling cellular genes that regulate cardiometabolic function.
[Cell Death & Disease]
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Upregulation of Glucocorticoid Receptor-Mediated Glucose Transporter 4 in Enzalutamide-Resistant Prostate Cancer

Inhibition of glucocorticoid receptor‐mediated glucose transporter 4 suppressed cell proliferation in enzalutamide (Enz)‐resistant prostate cancer cells, which recovered from Enz resistance and cross‐resistance without changes in glucocorticoid receptor expression.
[Cancer Science]
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Prokineticin Receptor 1 Ameliorates Insulin Resistance in Skeletal Muscle

Researchers measured the expression levels of Prokineticin receptor 1 (Prokr1) in the skeletal muscle of mice as well as human skeletal muscle cell‐derived myotubes. Prokineticin 2 (PROK2), a ligand of PROKR1, induced calcium mobilization in a dose‐dependent manner and altered the mRNA levels of 578 genes in PROKR1‐overexpressed HEK293T cells.
[FASEB Journal]
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Vagus Nerve Stimulation Optimized Cardiomyocyte Phenotype, Sarcomere Organization and Energy Metabolism in Infarcted Heart through FoxO3A-VEGF Signaling

VNS in vivo and acetylcholine in vitro optimized the levels of α/β-MHC and α-Actinin positive sarcomere organization in cardiomyocytes while reducing F-actin assembly of cardiomyocytes.
[Cell Death & Disease]
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Omidenepag, a Non-Prostanoid EP2 Receptor Agonist, Induces Enlargement of the 3D Organoid of 3T3-L1 Cells

Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes and the extracellular matrx, and the size and physical property of 3D organoids were compared between groups that had been treated with EP2 agonists and PGF2α.
[Scientific Reports]
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