Researchers measured the expression levels of Prokineticin receptor 1 (Prokr1) in the skeletal muscle of mice as well as human skeletal muscle cell‐derived myotubes. Prokineticin 2 (PROK2), a ligand of PROKR1, induced calcium mobilization in a dose‐dependent manner and altered the mRNA levels of 578 genes in PROKR1‐overexpressed HEK293T cells.
Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes and the extracellular matrx, and the size and physical property of 3D organoids were compared between groups that had been treated with EP2 agonists and PGF2α.
Ida, Y., Hikage, F., Umetsu, A., Ida, H., & Ohguro, H. (2020). Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells. Scientific Reports, 10(1), 16018. https://doi.org/10.1038/s41598-020-72538-xCite