Glut4

[Molecular Cell] By investigating insulin receptor signaling in human cells and biochemical reconstitution, scientists found that insulin induced the activation of mTORC2 toward AKT by assembling a supercomplex with KRAS4B and RHOA GTPases, termed KARATE (KRAS4B-RHOA-mTORC2 Ensemble).

[Communications Biology] Scientists showed a xanthene derivative, DS20060511, induced GLUT4 translocation to the skeletal muscle cell surface, thereby stimulating glucose uptake into the tissue.

[Scientific Reports] Investigators showed that intramuscular injection of placental (P)-MSCs homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.

[Cell Death & Disease] The authors revealed a series of key pathways and hub long non-coding RNAs involved in the malignant transformation of gastrointestinal stromal tumors (GISTs). DNM3OS promoted GIST cell proliferation and mitosis by regulating the expression of GLUT4 and CD36.

[Journal of Physiology] Muscle specific deletion of β-catenin induced in adult mice impaired both exercise and contraction (isolated muscle) induced glucose uptake without affecting running performance or canonical exercise signaling pathways.

[Cell Death & Disease] Scientists explore the emerging evidence that supports novel and important roles for the POU4F2/Brn-3b transcription factor in controlling cellular genes that regulate cardiometabolic function.