Prokineticin Receptor 1 Ameliorates Insulin Resistance in Skeletal Muscle

Researchers measured the expression levels of Prokineticin receptor 1 (Prokr1) in the skeletal muscle of mice as well as human skeletal muscle cell‐derived myotubes. Prokineticin 2 (PROK2), a ligand of PROKR1, induced calcium mobilization in a dose‐dependent manner and altered the mRNA levels of 578 genes in PROKR1‐overexpressed HEK293T cells.
[FASEB Journal]
Mok, J., Park, T. S., Kim, S., Kim, D., Choi, C. S., & Park, J. (n.d.). Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle. The FASEB Journal, n/a(n/a). https://doi.org/https://doi.org/10.1096/fj.202001641R Cite
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Vagus Nerve Stimulation Optimized Cardiomyocyte Phenotype, Sarcomere Organization and Energy Metabolism in Infarcted Heart through FoxO3A-VEGF Signaling

VNS in vivo and acetylcholine in vitro optimized the levels of α/β-MHC and α-Actinin positive sarcomere organization in cardiomyocytes while reducing F-actin assembly of cardiomyocytes.
[Cell Death & Disease]
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Omidenepag, a Non-Prostanoid EP2 Receptor Agonist, Induces Enlargement of the 3D Organoid of 3T3-L1 Cells

Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes and the extracellular matrx, and the size and physical property of 3D organoids were compared between groups that had been treated with EP2 agonists and PGF2α.
[Scientific Reports]
Ida, Y., Hikage, F., Umetsu, A., Ida, H., & Ohguro, H. (2020). Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells. Scientific Reports, 10(1), 16018. https://doi.org/10.1038/s41598-020-72538-x Cite
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