HIF-1a

[Signal Transduction and Targeted Therapy] Scientists confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells or postmortem lung T cells, and the infectious virus could also be detected from viral antigen-positive PBCs.

[Oncogene] Researchers reported that phenazine biosynthesis-like domain-containing protein (PBLD) inhibited hypoxia-induced angiogenesis via ERK/HIF-1a/VEGF axis in HCC cells.

[Oncogene] Phenazine biosynthesis-like domain-containing protein (PBLD) exerted an inhibitory effect on angiogenesis not only via blocking the VEGFR2 expression in endothelial cells, but also through downregulating HIF-1a-induced VEGF expression and secretion in hepatocellular carcinoma cells.

[Cell Stem Cell] Investigators reported that cardiac fibroblasts and mesenchymal progenitors are more hypoxic than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF-1α), and exhibited increased glycolytic metabolism.

[Cancer Cell International] Scientists describe the latest advances in the understanding of miRNAs and their corresponding targets that play a role in colorectal cancer angiogenesis and discuss possible miRNA-based therapeutic strategies.

[Bioprocess and Biosystems Engineering] Mouse clonal MSCs were cultured on a Cytodex 3 microcarrier in a spinner flask for a suspension culture under hypoxia condition to increase mass productivity.