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HIF

CircRBM33 Downregulation Inhibits Hypoxia-Induced Glycolysis and Promotes Apoptosis of Breast Cancer Cells via a MicroRNA-542-3p/HIF-1α Axis

[Cell Death Discovery] Breast cancer clinical tissue samples were collected to test differential expressions of circRBM33, miR-542-3p, and HIF-1α. MCF-7 cells were subjected to normoxia or hypoxia and transfected with plasmids that regulated CircRBM33, miR-542-3p, and HIF-1α expression levels.

Intramuscular Injection of Sotagliflozin Promotes Neovascularization in Diabetic Mice through Enhancing Skeletal Muscle Cells Paracrine Function

[Acta Pharmacologica Sinica] Researchers investigated whether sotagliflozin, an anti-hyperglycemia SGLT2 inhibitor, exerted therapeutic angiogenesis effects in diabetic HLI in vitro and in vivo.

Zinc Complex of 3,5-Di-Tert-Butyl Salicylate Inhibits Viability, Migration, and Invasion in Triple-Negative Breast Cancer Cells

[Scientific Reports] Investigators found that the zinc complex of 3,5-di-tert-butyl salicylate compound inhibited viability, invasion, and migration and induced apoptosis in triple-negative breast cancer 4T1 cells.

A Novel HIF-2α Targeted Inhibitor Suppresses Hypoxia-Induced Breast Cancer Stemness via SOD2-mtROS-PDI/GPR78-UPRER Axis

[Cell Death & Differentiation] Investigators illustrated that HIF-2α induced stemness in breast cancers under hypoxia through the SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum response via mitochondrial reactive oxygen species (mtROS) level.

A Novel HIF-2α Targeted Inhibitor Suppresses Hypoxia-Induced Breast Cancer Stemness via SOD2-mtROS-PDI/GPR78-UPRER Axis

[Cell Death & Differentiation] Scientists illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum (ER) response via mitochondrial reactive oxygen species (mtROS) level.

Hypoxia-Induced GLT8D1 Promotes Glioma Stem Cell Maintenance by Inhibiting CD133 Degradation through N-linked Glycosylation

[Cell Death & Differentiation] Depletion of glycosyltransferase 8 domain containing 1 (GLT8D1) inhibited self-renewal of glioma stem cells in vitro and repressed tumor growth in glioma mouse models.

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