HIF

[Nanomedicine] Investigators explored the effect of small extracellular vesicles from induced pluripotent stem cell-derived MSCs on acute pain and investigated the underlying mechanisms.

[Signal Transduction and Targeted Therapy] Scientists confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells or postmortem lung T cells, and the infectious virus could also be detected from viral antigen-positive PBCs.

[Cell Death & Disease] The biological effects of nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) and NR2F1 in pancreatic cancer were investigated by in vitro and in vivo experiments.

[Cell Death Discovery] Scientists analyzed the regulatory relationship of hypoxia and PVT1 and the mechanism of PVT1 in the hypoxia-induced chemoresistance process of lung cancer.

[Science Advances] Researchers performed multiplex ELISA angiogenesis arrays on aqueous fluid from proliferative diabetic retinopathy patients who responded inadequately to anti-VEGF therapy and/or pan-retinal laser photocoagulation and identified plasminogen activator inhibitor-1 (PAI-1).

[Journal of Clinical Investigation] The authors reported that targeting of HIF-1α suppressed PD-L1 expression on tumor cells and tumor-infiltrated myeloid cells, but unexpectedly induced PD-L1 in normal tissues by an IFNγ–dependent mechanism.