HIF

[Radiotherapy and Oncology] The authors investigated the effect of a novel oxygen-generating polymer-lipid manganese dioxide nanoparticle on improving radiation therapy (RT) outcomes in CRPC xenograft models by modulating the tumor microenvironment both before and after RT.

[Cell Death & Disease] The authors reported that hypoxia-inducible factor 1α (HIF-1α) was upregulated after ATP treatment and mediated the ATP-driven chemoresistance process.

[EMBO Journal] USP33 was preferentially induced in glioma stem cells by hypoxia and interacts with HIF-2alpha, leading to its stabilization through deubiquitination.

[EMBO Journal] Researchers identified USP33 as essential deubiquitinase that stabilized HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells.

[Bone Research] Using genetically modified mice and high-throughput analyses, scientists demonstrated that prolonged hypoxia-inducible factor (HIF)-1α signaling in B cells led to enhanced eceptor activator of nuclear factor kappa-Β production and osteoclast formation.

[Nature Communications] Investigators showed that macropinocytosis occurred universally in HCC under hypoxia. HIF-1 activated the transcription of a membrane ruffling protein, EH domain-containing protein 2, to initiate macropinocytosis.