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HIF

Increased Expression of PD-L1 in Endometrial Cancer Stem-Like Cells Is Regulated by Hypoxia

[Frontiers in Bioscience-Landmark] Using flow cytometry and western blot assays, the authors have demonstrated that programmed cell death ligand 1 expression is higher in endometrial cancer stem-like cell derived from endometrial cancer than in nonstem-like cancer cells.

microRNA-124-3p Attenuates Myocardial Injury in Sepsis via Modulating SP1/HDAC4/HIF-1α Axis

[Cell Death Discovery] Septic rats were modeled by cecal ligation puncture while in vitro septic cardiomyocyte H9C2 were induced by lipopolysaccharide.

SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth

[American Journal of Pathology] Downregulation of SET-domain containing 5 (SETD5) significantly decreased breast cancer stem-like cells properties and glycolysis in vitro and in vivo.

EDDM3A Drives Gastric Cancer Progression by Promoting HIF-1α-Dependent Aerobic Glycolysis

[Oncogenesis] Researchers showed that the expression of EDDM3A was significantly upregulated in gastric cancer tissues and its upregulation correlates with poorer survival in patients with gastric cancer.

Targeting HIF-1α/NOTCH1 Pathway Eliminates CD44+ Cancer Stem-Like Cell Phenotypes, Malignancy, and Resistance to Therapy in Head and Neck Squamous Cell Carcinoma

[Oncogene] Scientists compared the gene expression between CD44+ and CD44− HNSCC cells and assessed the correlation of CD44 and hypoxia-inducible factor 1α expression with mouse features and outcomes of patients with head and neck squamous cell carcinomas.

Induction of Cancer Cell Stemness in Glioma through Glycolysis and the Long Noncoding RNA HULC-Activated FOXM1/AGR2/HIF-1α Axis

[Laboratory Investigation] Brain tissues were clinically collected from 50 patients with glioblastoma and 35 patients with acute craniocerebral injury, followed by immunohistochemical detection of the expression patterns of Forkhead box M1, anterior gradient 2, and hypoxia-inducible factor-1α.

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