HIV

[Journal of Clinical Investigation] The authors observed that the HIV-1 proviral landscape was different and changed with time on antiretroviral therapy across naïve and memory CD4+ T cell subsets isolated from 24 participants.

[Scientific Reports] Investigators reported the generation of neurospheres from iPSC-derived neural progenitor cells and showed that these cultures were permissive to retroviral replication.

[Nature Communications] The authors showed that DNA-encoded native-like trimer fold properly in vivo and induced autologous tier-2 neutralizing antibodies in mice.

[Journal of Virology] Scientists assessed the antiviral efficacy of HIV-specific iPSC-cytotoxic T lymphocytes by single- and multiple-round viral suppression assays.

[American Journal of Pathology] Poorly formed necrotic tuberculosis (TB) granulomas containing a high expression of Mycobacterium tuberculosis antigens were elevated in TB/HIV co-infected lymph nodes, and inducible nitric oxide synthase as well as Arg-1 expression was significantly higher in TB/HIV co-infected compared to HIV-negative TB or control tissues.

[Journal of Virology] Researchers showed that the combined expression of Nef and Vpu predicted the susceptibility of HIV-1-infected primary CD4+ T cells to antibody-dependent cellular cytotoxicity by HIV+ plasma.