HIV

[Nature Reviews Disease Primers] VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.

[Molecular Neurodegeneration] Investigators determined whether HIV-1 infection caused Alzheimer’s Disease-like pathologies in an HIV/AIDS humanized mouse model, and whether the CCR5 antagonist maraviroc altered HIV-induced pathologies.

[Immunity] Scientists found that skin CD4+ tissue-resident memory T cells were depleted after HIV infection and replenished only upon early antiretroviral therapy initiation.

[BMC Medicine] Scientists conducted a genome-wide quantitative trait locus analysis to probe functionally relevant genetic variants linked to levels of cell-associated HIV-1 DNA, CA HIV-1 RNA, and RNA:DNA ratio in CD4+ T cells isolated from blood from a cohort of 207 people living with HIV-1 on long-term suppressive antiretroviral treatment

[Nature Communications] Tamoxifen-inducible and microglia-specific depletion of polyglutamine binding protein 1 (PQBP1) in primary culture in vitro and mouse brain in vivo showed that PQBP1 was essential for sensing-tau to induce nuclear translocation of nuclear factor κB (NFκB).

[Proceedings of the National Academy of Sciences of the United States of America] Invariant natural killer T (iNKT) cells from peripheral blood and colonic mucosa were investigated during treated and untreated acute HIV-1 infection.