Umbilical Cord-Derived MSC and Hyperbaric Oxygen Therapy Effectively Protected the Brain in Rat after Acute Intracerebral Haemorrhage

Scientists tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells and hyperbaric oxygen was superior to either one on preserving neurological function and reducing brain haemorrhagic volume in rat after acute intracerebral haemorrhage induced by intracranial injection of collagenase.
[Journal of Cellular and Molecular Medicine]
Yip, H.-K., Lin, K.-C., Sung, P.-H., Chiang, J. Y., Yin, T.-C., Wu, R.-W., & Chen, K.-H. (n.d.). Umbilical cord-derived MSC and hyperbaric oxygen therapy effectively protected the brain in rat after acute intracerebral haemorrhage. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16577 Cite
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Oleandrin, a Cardiac Glycoside, Induces Immunogenic Cell Death via the PERK/elF2α/ATF4/CHOP Pathway in Breast Cancer

Researchers showed that oleandrin treatment triggered breast cancer cell immunogenic cell death by inducing calreticulin exposure on cell surface and the release of high-mobility group protein B1, heat shock protein 70/90, and adenosine triphosphate.
[Cell Death & Disease]
Li, X., Zheng, J., Chen, S., Meng, F., Ning, J., & Sun, S. (2021). Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03605-y Cite
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Disulfide HMGB1 Acts via TLR2/4 Receptors to Reduce the Numbers of Oligodendrocyte Progenitor Cells after Traumatic Injury In Vitro

Researchers established unequivocal evidence that high-mobility group box-1 (HMGB1) released in vitro impairs oligodendrocyte progenitor cell response to mechanical injury; an effect that is pharmacologically reversible.
[Scientific Reports]
Ved, R., Sharouf, F., Harari, B., Muzaffar, M., Manivannan, S., Ormonde, C., Gray, W. P., & Zaben, M. (2021). Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro. Scientific Reports, 11(1), 6181. https://doi.org/10.1038/s41598-021-84932-0 Cite
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GSDME-Mediated Pyroptosis Promotes Inflammation and Fibrosis in Obstructive Nephropathy

Using bone marrow transplantation and cell type-specific Casp3 knockout mice, scientists demonstrated that Casp3/GSDME-mediated pyroptosis in renal parenchymal cells, but not in hematopoietic cells, played predominant roles in this process.
[Cell Death & Differentiation]
Li, Y., Yuan, Y., Huang, Z., Chen, H., Lan, R., Wang, Z., Lai, K., Chen, H., Chen, Z., Zou, Z., Ma, H., Lan, H.-Y., Mak, T. W., & Xu, Y. (2021). GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy. Cell Death & Differentiation, 1–18. https://doi.org/10.1038/s41418-021-00755-6 Cite
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A Surfactant Polymer Wound Dressing Protects Human Keratinocytes from Inducible Necroptosis

Researchers showed that TX100-induced plasma membrane damage and death by necroptosis were both attenuated by surfactant polymer dressing, allowing keratinocyte survival.
[Ca-A Cancer Journal For Clinicians]
Khandelwal, P., Das, A., Sen, C. K., Srinivas, S. P., Roy, S., & Khanna, S. (2021). A surfactant polymer wound dressing protects human keratinocytes from inducible necroptosis. Scientific Reports, 11(1), 4357. https://doi.org/10.1038/s41598-021-82260-x Cite
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Akt‐Independent Effects of Triciribine on ACE2 Expression in Human Lung Epithelial Cells: Potential Benefits in Restricting SARS‐CoV2 Infection

Investigators tested the direct effect of triciribine on ACE2 expression in human bronchial (H441) and lung alveolar (A549) epithelial cells.
[Journal of Cellular Physiology]
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Verbascoside Inhibits the Epithelial-Mesenchymal Transition of Prostate Cancer Cells through High-Mobility Group Box 1/Receptor for Advanced Glycation End-Products/TGF-β Pathway

Investigators evaluated the effects of purified verbascoside on human prostate cancer and the associated molecular mechanisms.
[Environmental Toxicology]
Wu, C.-H., Chen, C.-H., Hsieh, P.-F., Lee, Y.-H., Kuo, W. W.-T., Wu, R. C.-Y., Hung, C.-H., Yang, Y.-L., & Lin, V. C. (n.d.). Verbascoside inhibits the epithelial-mesenchymal transition of prostate cancer cells through high-mobility group box 1/receptor for advanced glycation end-products/TGF-β pathway. Environmental Toxicology, n/a(n/a). https://doi.org/https://doi.org/10.1002/tox.23107 Cite
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Oxidized Phosphatidylcholines Trigger Ferroptosis in Cardiomyocytes during Ischemia/Reperfusion Injury

Cardiomyocyte viability, bioenergetic response and calcium transients were determined in the presence of oxidized phosphatidylcholines (OxPCs). Fragmented OxPCs resulted in a decrease in cell viability with POVPC and PONPC having the most potent cardiotoxic effect in both a concentration and time dependent manner.
[American Journal of Physiology-Heart and Circulatory Physiology]
Stamenkovic, A., O’Hara, K. A., Nelson, D. C., Maddaford, T. G., Edel, A. L., Maddaford, G., Dibrov, E., Aghanoori, M., Kirshenbaum, L. A., Fernyhough, P., Aliani, M., Pierce, G. N., & Ravandi, A. (2021). Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia/reperfusion injury. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00237.2020 Cite
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HMGB1-Mediated Chromatin Remodeling Attenuates Il24 Gene Expression for the Protection from Allergic Contact Dermatitis

Researchers generated conditional knockout mice in which the High-mobility group box 1 protein (HMGB1) gene was specifically deleted in keratinocytes, and examined its role in allergic contact dermatitis models.
[Proceedings of the National Academy of Sciences of the United States of America]
Senda, N., Yanai, H., Hibino, S., Li, L., Mizushima, Y., Miyagaki, T., Saeki, M., Kishi, Y., Hangai, S., Nishio, J., Sugaya, M., Taniguchi, T., & Sato, S. (2021). HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis. Proceedings of the National Academy of Sciences, 118(1). https://doi.org/10.1073/pnas.2022343118 Cite
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Sirtuin 1-Dependent Regulation of High Mobility Box 1 in Hypoxia–Reoxygenated Brain Microvascular Endothelial Cells: Roles in Neuronal Amyloidogenesis

Scientists investigated the roles of hypoxia–reoxygenation-induced release of high mobility group box protein 1, a risk molecule for Alzheimer’s disease pathogenesis in the ischaemic damaged brain, from human brain microvascular endothelial cells in neuronal amyloid-beta production.
[Cell Death & Disease]
Lee, Y.-S., Choi, J.-Y., Mankhong, S., Moon, S., Kim, S., Koh, Y. H., Kim, J.-H., & Kang, J.-H. (2020). Sirtuin 1-dependent regulation of high mobility box 1 in hypoxia–reoxygenated brain microvascular endothelial cells: roles in neuronal amyloidogenesis. Cell Death & Disease, 11(12), 1–12. https://doi.org/10.1038/s41419-020-03293-0 Cite
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HMGB1 as a Potential Biomarker and Therapeutic Target for Severe COVID-19

Researchers report that high mobility group box 1, a prototypical damage-associated molecular pattern and a central mediator of lethal inflammation, could be a potential target for innovative therapeutic strategies for COVID-19.
[Heliyon]
Chen, R., Huang, Y., Quan, J., Liu, J., Wang, H., Billiar, T. R., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2020). HMGB1 as a Potential Biomarker and Therapeutic Target for Severe COVID-19. Heliyon, 0(0). https://doi.org/10.1016/j.heliyon.2020.e05672 Cite
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