Exosomes Derived from miR-129-5p Modified Bone Marrow Mesenchymal Stem Cells Represses Ventricular Remolding of Mice with Myocardial Infarction

Researchers found that miR-129-5p inhibited high mobility group box 1 (HMGB1) expression in bone marrow MSCs. Myocardial infraction mice treated with exosomes overexpressing miR-129-5p had enhanced cardiac function and decreased expression of HMGB1 and production of inflammatory cytokines.
[Journal of Tissue Engineering and Regenerative Medicine]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Genetic Inhibition of RIPK3 Ameliorates Functional Outcome in Controlled Cortical Impact Independent of Necroptosis

Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.
[Cell Death & Disease]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine Induces Immunogenic Cell Death in Colon and Pancreatic Carcinoma Models as a Single Agent

RNA sequencing experiments were conducted on PANC-1 human pancreatic cancer cells treated with Docosahexaenoyl difluorodeoxycytidine (DHA–dFdC), dFdC, or vehicle control in vitro.
[Cancer Chemotherapy and Pharmacology]
[zotpress userid=” items=’ARAWWKA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Autophagic Secretion of HMGB1 from Cancer-Associated Fibroblasts Promotes Metastatic Potential of Non-Small Cell Lung Cancer Cells via NFκB Signaling

Researchers reported that autophagy was upregulated in lung cancer-associated cancer-associated fibroblasts (CAFs) compared to normal fibroblasts, and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer cell migration and invasion.
[Cell Death & Disease]
[zotpress userid=” items=’4ZD78FER’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

LL-37 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE

The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
[zotpress userid=” items=’N9D8UDGJ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

LL-37 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE

The effects of the receptor for advanced glycation end-products (RAGE) ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
[zotpress userid=” items=’I3R762Q3′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

lncRNA ANRIL Aggravates the Chemoresistance of Pancreatic Cancer Cells to Gemcitabine by Targeting Inhibition of miR-181a and Targeting HMGB1-Induced Autophagy

Researchers showed that ANRIL was up-regulated while miR-181a was down-regulated in pancreatic cancer tissues and HMGB1 was highly expressed. Knockdown of ANRIL in pancreatic cancer repressed cellular proliferation, invasion, migration, and reduced chemotherapy resistance to gemcitabine.
[Aging]
[zotpress userid=” items=’QPTIS88H’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Long Noncoding RNA BS-DRL1 Modulates the DNA Damage Response and Genome Stability by Interacting with HMGB1 in Neurons

Researchers reported and characterized a long noncoding RNA, termed Brain Specific DNA-damage Related lncRNA1 (BS-DRL1), in the central nervous system.
[Nature Communications]
[zotpress userid=’7753456′ items=’VTF2MVEZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

miR-141-5p Suppresses Vascular Smooth Muscle Cell Inflammation, Proliferation, and Migration via Inhibiting the HMGB1/NF-κB Pathway

Using human vascular smooth muscle cells (VSMCs) treated by oxidized low-density lipoprotein to establish an atherosclerosis cell model, researchers explored the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction.
[Journal of Biochemical and Molecular Toxicology]
[zotpress userid=’7992332′ items=’GSSA9HYW’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

HIF-1α Is a Negative Regulator of Interferon Regulatory Factors: Implications for Interferon Production by Hypoxic Monocytes

To understand the pathophysiology of COVID-19 infection, it is necessary to understand cell function during hypoxia. Researchers investigated aspects of human monocyte activation under hypoxic conditions.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=’6445218′ items=’9IRI46TP’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Rebalancing Expression of HMGB1 Redox Isoforms to Counteract Muscular Dystrophy

Researchers identified the alarmin high-mobility group box 1 (HMGB1) as a functional link between oxidative stress and inflammation in muscular dystrophies and demonstrated that the balance between HMGB1 redox isoforms dictated whether skeletal muscle was in an inflamed or regenerating state.
[Science Translational Medicine]
[zotpress userid=” items=’ZJFZ65V7′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share