Tag results:
HMGB1
Dermal Cell News
PLP2-Derived Peptide Rb4 Triggers PARP-1-Mediated Necrotic Death in Murine Melanoma Cells
[Scientific Reports] Researchers studied the antitumor activity of peptide Rb4 derived from Proteolipid protein 2 (PLP2). In vitro, Rb4 induced F-actin polymerization, prevented F-actin depolymerization and increased the ER-derived cytosolic calcium.
Endothelial Cell News
Endothelial Cell Ferroptosis Mediates Monocrotaline-Induced Pulmonary Hypertension in Rats by Modulating NLRP3 Inflammasome Activation
[Scientific Reports] The effects of the ferroptosis inhibitor ferrostatin-1 on endothelial cell ferroptosis and pulmonary vascular remodelling in monocrotaline-induced rats were studied in vitro and in vivo.
Neural Cell News
Autophagy-Based Unconventional Secretion of HMGB1 in Glioblastoma Promotes Chemosensitivity to Temozolomide through Macrophage M1-Like Polarization
[Journal of Experimental & Clinical Cancer Research] The authors demonstrated that enhanced secretory autophagy in glioblastoma (GB) facilitated M1-like polarization of tumor associated macrophages to enhance temozolomide sensitivity of GB cells.
Endothelial Cell News
TIRAP Drives Myelosuppression through an Ifnγ–Hmgb1 Axis That Disrupts the Endothelial Niche in Mice
[Journal of Experimental Medicine] The authors showed that toll/interleukin-1 receptor domain containing adaptor protein (TIRAP) was overexpressed in various types of myelodysplastic syndromes and suppressed all three major hematopoietic lineages.
Hematopoiesis News
Deubiquitylase USP12 Induces Pro-Survival Autophagy and Bortezomib Resistance in Multiple Myeloma by Stabilizing HMGB1
[Oncogene] Researchers identified an important role of the deubiquitylase ubiquitin-specific protease-12 (USP12) in pro-survival autophagy and resultant bortezomib resistance in multiple myeloma by stabilizing high mobility group box-1 (HMGB1).
Pulmonary Cell News
Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema
[Chemico-Biological interactions] Researchers investigated the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure.