HMGB1

[Journal of Tissue Engineering and Regenerative Medicine] Researchers found that miR-129-5p inhibited high mobility group box 1 (HMGB1) expression in bone marrow MSCs. Myocardial infraction mice treated with exosomes overexpressing miR-129-5p had enhanced cardiac function and decreased expression of HMGB1 and production of inflammatory cytokines.

[Cell Death & Disease] Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.

[Cancer Chemotherapy and Pharmacology] RNA sequencing experiments were conducted on PANC-1 human pancreatic cancer cells treated with Docosahexaenoyl difluorodeoxycytidine (DHA–dFdC), dFdC, or vehicle control in vitro.

[Cell Death & Disease] Researchers reported that autophagy was upregulated in lung cancer-associated cancer-associated fibroblasts (CAFs) compared to normal fibroblasts, and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer cell migration and invasion.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The effects of the receptor for advanced glycation end-products (RAGE) ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.