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Hras

Co-Occurrence CDK4/6 Amplification Serves as Biomarkers of De Novo EGFR TKI Resistance in Sensitizing EGFR Mutation Non-Small Cell Lung Cancer

[Scientific Reports] Scientists explored clinical factors in 332 advanced NSCLC who received EGFR TKI and molecular characteristics through 65 whole exome sequencing of various EGFR TKI responses including; de novo, intermediate response and long-term response.

K15 Promoter-Driven Enforced Expression of NKIRAS Exhibits Tumor Suppressive Activity against the Development of DMBA/TPA-Induced Skin Tumors

[Scientific Reports] Researchers clarified how NKIRAS acted on cellular transformation, and generated transgenic mice in which NKIRAS2 was forcibly expressed using a cytokeratin 15 promoter, which was mainly activated in follicle bulge cells.

RAS Specific Protease Induces Irreversible Growth Arrest via p27 in Several KRAS Mutant Colorectal Cancer Cell Lines

[Scientific Reports] Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.

Dysregulated ECM Remodeling Proteins Lead to Aberrant Osteogenesis of Costello Syndrome iPSCs

[Stem Cell Reports] Scientists used Costello syndrome induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.

ARHGEF19 Regulates MAPK/ERK Signaling and Promotes the Progression of Small Cell Lung Cancer

[Biochemical and Biophysical Research Communications] Enforced ARHGEF19 expression promotes small cell lung cancer cell proliferation in vitro and its knockdown decreases cell proliferation in vitro and in vivo.

Costello Syndrome Model Mice with a Hras G12S Mutation Are Susceptible to Develop House Dust Mite-Induced Atopic Dermatitis

[Cell Death & Disease] Cultured HrasG12S/+ keratinocytes exhibited increased IL-33 expression after Dermatophagoides farinae stimulation.

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