Tag results:
Hras
Pulmonary Cell News
Co-Occurrence CDK4/6 Amplification Serves as Biomarkers of De Novo EGFR TKI Resistance in Sensitizing EGFR Mutation Non-Small Cell Lung Cancer
[Scientific Reports] Scientists explored clinical factors in 332 advanced NSCLC who received EGFR TKI and molecular characteristics through 65 whole exome sequencing of various EGFR TKI responses including; de novo, intermediate response and long-term response.
Dermal Cell News
K15 Promoter-Driven Enforced Expression of NKIRAS Exhibits Tumor Suppressive Activity against the Development of DMBA/TPA-Induced Skin Tumors
[Scientific Reports] Researchers clarified how NKIRAS acted on cellular transformation, and generated transgenic mice in which NKIRAS2 was forcibly expressed using a cytokeratin 15 promoter, which was mainly activated in follicle bulge cells.
Intestinal Cell News
RAS Specific Protease Induces Irreversible Growth Arrest via p27 in Several KRAS Mutant Colorectal Cancer Cell Lines
[Scientific Reports] Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.
ESC & iPSC News
Dysregulated ECM Remodeling Proteins Lead to Aberrant Osteogenesis of Costello Syndrome iPSCs
[Stem Cell Reports] Scientists used Costello syndrome induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.
Pulmonary Cell News
ARHGEF19 Regulates MAPK/ERK Signaling and Promotes the Progression of Small Cell Lung Cancer
[Biochemical and Biophysical Research Communications] Enforced ARHGEF19 expression promotes small cell lung cancer cell proliferation in vitro and its knockdown decreases cell proliferation in vitro and in vivo.
Dermal Cell News
Costello Syndrome Model Mice with a Hras G12S Mutation Are Susceptible to Develop House Dust Mite-Induced Atopic Dermatitis
[Cell Death & Disease] Cultured HrasG12S/+ keratinocytes exhibited increased IL-33 expression after Dermatophagoides farinae stimulation.