Investigators showed that the nucleocapsid of SARS-CoV-2 inhibited host pyroptosis by blocking Gasdermin D cleavage. SARS-CoV-2-infected monocytes showed enhanced cellular interleukin 1b (IL-1b) expression, but reduced IL-1b secretion.
Scientists investigated how IL-1B from tumour cells and the microenvironment interacted to affect primary tumour growth and bone metastasis through regulation of the immune system, and whether targeting IL-1 driven changes to the immune response improved standard of care therapy for breast cancer bone metastasis.
Sanie-Jahromi, F., Nowroozzadeh, M. H., Khodabandeh, Z., Soheili, Z.-S., Khajehahmadi, Z., Emadi, Z., & Talebnejad, M. R. (2021). Effects of the secretome of human Wharton’s jelly mesenchymal stem cells on the proliferation and apoptosis gene expression of the retinal pigmented epithelium. Experimental Eye Research, 205, 108528. https://doi.org/10.1016/j.exer.2021.108528Cite
Scientists investigated their interplay in vascular smooth muscle cell inflammation. Chromatin immunoprecipitation followed by high-throughput sequencing revealed H3K27ac/BRD4 enrichment at CCAAT enhancer binding protein delta (Cebpd) in injured rat carotid arteries.
To analyze the effect of NF-kB signaling in myofibroblasts (MFs), researchers crossed L2-IL-1B mice to tamoxifen inducible Vim-Cre mice and floxed RelA mice to specifically eliminate NF-kB signaling in MF. The interaction of epithelial cells and stromal cells was further analyzed in mouse Barrett Esophagus organoids and patient-derived human organoids.
Anand, A., Fang, H.-Y., Mohammad Shahi, D., Ingermann, J., Baumeister, T., Strangmann, J., Wang, T. C., & Quante, M. (n.d.). Elimination of Nf-kB signaling in Vimentin+ stromal cells attenuates tumorigenesis in a mouse model of Barrett Esophagus. Carcinogenesis. https://doi.org/10.1093/carcin/bgaa109Cite