SARS-CoV-2 Nucleocapsid Suppresses Host Pyroptosis by Blocking Gasdermin D Cleavage

Investigators showed that the nucleocapsid of SARS-CoV-2 inhibited host pyroptosis by blocking Gasdermin D cleavage. SARS-CoV-2-infected monocytes showed enhanced cellular interleukin 1b (IL-1b) expression, but reduced IL-1b secretion.
[EMBO Journal]
SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage. (2021). The EMBO Journal, n/a(n/a), e108249. https://doi.org/10.15252/embj.2021108249 Cite
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IL-1B Drives Opposing Responses in Primary Tumors and Bone Metastasis; Harnessing Combination Therapies to Improve Outcome in Breast Cancer

Scientists investigated how IL-1B from tumour cells and the microenvironment interacted to affect primary tumour growth and bone metastasis through regulation of the immune system, and whether targeting IL-1 driven changes to the immune response improved standard of care therapy for breast cancer bone metastasis.
[npj Breast Cancer]
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Effects of the Secretome of Human Wharton’s Jelly Mesenchymal Stem Cells on the Proliferation and Apoptosis Gene Expression of the Retinal Pigmented Epithelium

Scientists evaluated the effect of the conditioned medium secreted by human Wharton’s jelly MSCs (WJMSCs-CM) on the proliferation and apoptosis gene expression of the retinal pigmented epithelium.
[Experimental Eye Research]
Sanie-Jahromi, F., Nowroozzadeh, M. H., Khodabandeh, Z., Soheili, Z.-S., Khajehahmadi, Z., Emadi, Z., & Talebnejad, M. R. (2021). Effects of the secretome of human Wharton’s jelly mesenchymal stem cells on the proliferation and apoptosis gene expression of the retinal pigmented epithelium. Experimental Eye Research, 205, 108528. https://doi.org/10.1016/j.exer.2021.108528 Cite
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A Hierarchical and Collaborative BRD4/CEBPD Partnership Governs Vascular Smooth Muscle Cell Inflammation

Scientists investigated their interplay in vascular smooth muscle cell inflammation. Chromatin immunoprecipitation followed by high-throughput sequencing revealed H3K27ac/BRD4 enrichment at CCAAT enhancer binding protein delta (Cebpd) in injured rat carotid arteries.
[Molecular Therapy-Methods & Clinical Development]
Wang, Q., Ozer, H. G., Wang, B., Zhang, M., Urabe, G., Huang, Y., Kent, K. C., & Guo, L.-W. (2021). A hierarchical and collaborative BRD4/CEBPD partnership governs vascular smooth muscle cell inflammation. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.02.021 Cite
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Elimination of Nf-kB Signaling in Vimentin+ Stromal Cells Attenuates Tumorigenesis in a Mouse Model of Barrett Esophagus

To analyze the effect of NF-kB signaling in myofibroblasts (MFs), researchers crossed L2-IL-1B mice to tamoxifen inducible Vim-Cre mice and floxed RelA mice to specifically eliminate NF-kB signaling in MF. The interaction of epithelial cells and stromal cells was further analyzed in mouse Barrett Esophagus organoids and patient-derived human organoids.
[Carcinogenesis]
Anand, A., Fang, H.-Y., Mohammad Shahi, D., Ingermann, J., Baumeister, T., Strangmann, J., Wang, T. C., & Quante, M. (n.d.). Elimination of Nf-kB signaling in Vimentin+ stromal cells attenuates tumorigenesis in a mouse model of Barrett Esophagus. Carcinogenesis. https://doi.org/10.1093/carcin/bgaa109 Cite
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