IL-23

[Cell Reports] Scientists showed that intestine-draining mesenteric lymph nodes, not intestine proper, were the dominant site of segmented filamentous bacteria-induced intestinal Th17 cell differentiation.

[Nature Communications] Lesional skin of non-responders contains higher numbers of dermal dendritic cells expressing the maturation marker CD83 and producing IL-23, and increased numbers of IL-17+ T cells.

[Respiratory Research] Sensitized BALB/c mice were challenged with aerosolized ovalbumin (OVA) to establish allergic inflammation, followed by RSV-A2 infection to yield four treatment groups: saline only, RSV-infected alone, OVA alone, and OVA-treated with RSV infection

[Nature Medicine] Investigators studied a patient with inherited PD-1 deficiency and tuberculosis who died of pulmonary autoimmunity. The patient’s leukocytes did not express PD-1 or respond to PD-1-mediated suppression.

[Scientific Reports] In lieu of tissue samples, investigators measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients.

[Cell Metabolism] Investigators showed that the azo dyes Red 40 and Yellow 6, the most abundant food colorants in the world, could trigger an IBD-like colitis in mice conditionally expressing interluekin (IL)-23, or in two additional animal models in which IL-23 expression was augmented.