Tag results:
IL-23
Intestinal Cell News
Redundant Cytokine Requirement for Intestinal Microbiota-Induced Th17 Cell Differentiation in Draining Lymph Nodes
[Cell Reports] Scientists showed that intestine-draining mesenteric lymph nodes, not intestine proper, were the dominant site of segmented filamentous bacteria-induced intestinal Th17 cell differentiation.
Dermal Cell News
Enhanced NF-κB Signaling in Type-2 Dendritic Cells at Baseline Predicts Non-Response to Adalimumab in Psoriasis
[Nature Communications] Lesional skin of non-responders contains higher numbers of dermal dendritic cells expressing the maturation marker CD83 and producing IL-23, and increased numbers of IL-17+ T cells.
Immune Regulation News
Neutralization of IL-33 Modifies the Type 2 and Type 3 Inflammatory Signature of Viral Induced Asthma Exacerbation
[Respiratory Research] Sensitized BALB/c mice were challenged with aerosolized ovalbumin (OVA) to establish allergic inflammation, followed by RSV-A2 infection to yield four treatment groups: saline only, RSV-infected alone, OVA alone, and OVA-treated with RSV infection
Immunology of Infectious Disease News
Inherited PD-1 Deficiency Underlies Tuberculosis and Autoimmunity in a Child
[Nature Medicine] Investigators studied a patient with inherited PD-1 deficiency and tuberculosis who died of pulmonary autoimmunity. The patient’s leukocytes did not express PD-1 or respond to PD-1-mediated suppression.
Immunology of Infectious Disease News
Limited Intestinal Inflammation despite Diarrhea, Fecal Viral RNA and SARS-CoV-2-Specific IgA in Patients with Acute COVID-19
[Scientific Reports] In lieu of tissue samples, investigators measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients.
Immune Regulation News
Food Colorants Metabolized by Commensal Bacteria Promote Colitis in Mice with Dysregulated Expression of Interleukin-23
[Cell Metabolism] Investigators showed that the azo dyes Red 40 and Yellow 6, the most abundant food colorants in the world, could trigger an IBD-like colitis in mice conditionally expressing interluekin (IL)-23, or in two additional animal models in which IL-23 expression was augmented.