Effect of 1-MHz Ultrasound on the Proinflammatory Interleukin-6 Secretion in Human Keratinocytes

Researchers investigated whether mechanical energy transported by low intensity ultrasound could generate a mechanical stress able to induce the release of inflammatory cytokine such as interleukin-6 in the human keratinocyte cell line, HaCaT.
[Scientific Reports]
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IRF-4 Deficiency Reduces Inflammation and Kidney Fibrosis after Folic Acid-Induced Acute Kidney Injury

Scientists examined the effect of interferon regulatory factor 4 (IRF-4) deficiency on inflammation and kidney fibrosis in an acute kidney injury-chronic kidney disease transition model induced by folic acid injury.
[International Immunopharmacology]
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Chronic Prostatitis and Pelvic Pain Syndrome: Another Autoimmune Disease?

After generally reviewing and comparing the inflammatory responses in autoimmune diseases and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), the authors presume that CP/CPPS is more likely to be defined as an autoimmune disease.
[Archivum Immunologiae et Therapiae Experimentalis]
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Rutin Inhibited the Advanced Glycation End Products-Stimulated Inflammatory Response and Extracellular Matrix Degeneration via Targeting TRAF-6 and BCL-2 Proteins in Mouse Model of Osteoarthritis

Scientists screened rutin (RT) for its activity against osteoarthritis with in vivo and in vitro models of osteoarthritis. Pretreatment of RT decreased the ECM degradation, inhibited expression of TRAF-6 and BCL-2 the NF-κB/MAPK pathway proteins.
[Aging]
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Doxorubicin Suppresses Chondrocyte Differentiation by Stimulating ROS Production

Scientists explored the specific mechanism of doxorubicin in osteoarthritis (OA). A mouse OA model was established by destabilizing the medial meniscus, and the role of DOX was determined by intraperitoneally injecting five or ten mg/kg DOX.
[European Journal of Pharmaceutical Sciences]
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Histone Deacetylase HDAC4 Participates in the Pathological Process of Myocardial Ischemia-Reperfusion Injury via MEKK1/JNK Pathway by Binding to miR-206

Investigators defined the underlying role of histone deacetylase 4 (HDAC4) and miR-206 in the pathological process of myocardial ischemia-reperfusion injury (MIRI). Up-regulation of HDAC4 and down-regulation of miR-206 occurred in rat myocardial tissues and cardiomyocytes in MIRI.
[Cell Death Discovery]
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Extracellular Vesicles Derived from CD73 Modified Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation after Spinal Cord Injury

Effects of CD73+ human umbilical cord MSC-EVs on hydrolyzing ATP into adenosine were detected. The polarization of M2/M1 was verified by immunofluorescence.
[Journal of Nanobiotechnology]
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Targeting Tumor-Stromal IL-6/STAT3 Signaling through IL-1 Receptor Inhibition in Pancreatic Cancer

Investigators showed that IL-1α was overexpressed in both murine and human pancreatic ductal adenocarcinomatumors and engaged with its cognate receptor IL-1R1 which was strongly expressed on stromal cells.
[Molecular Cancer Therapeutics]
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DNAM-1/CD226 Is Functionally Expressed on Acute Myeloid Leukemia (AML) Cells and Is Associated with Favorable Prognosis

Investigators analyzed expression of DNAM-1 in leukemic cells of AML patients. Interaction of DNAM-1 with its ligands CD112 and CD155 induced release of the immunomodulatory cytokines IL-6, IL-8 IL-10 and TNF-α by AML cells and DNAM-1 expression correlated with a more differentiated phenotype.
[Scientific Reports]
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gp130 Cytokines Activate Novel Signaling Pathways and Alter Bone Dissemination in ER+ Breast Cancer Cells

In estrogen receptor positive (ER+) cells, oncostatin M (OSM) robustly stimulated phosphorylation of known gp130 signaling targets STAT3, ERK and AKT, while CNTF activated STAT3 signaling. In ER breast cancer cells, OSM alone stimulated AKT and ERK signaling.
[Journal of Bone and Mineral Research]
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Human Induced Pluripotent Stem Cell-Derived Macrophages Ameliorate Liver Fibrosis

Investigators demonstrated that treatment of liver fibrosis with both human induced pluripotent stem cell-derived macrophage populations and especially M2 subtype significantly reduced fibrogenic gene expression and disease associated histological markers in immunodeficient Rag2−/−γc−/− mice model, making this approach a promising cell-based avenue to ameliorate fibrosis.
[Stem Cells]
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