IL-6

[Nature Cancer] By screening a collection of small-molecule compounds, investigators found that inhibiting β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) with MK-8931 potently reprogrammed tumor-promoting macrophages into tumor-suppressive macrophages and promotes macrophage phagocytosis of glioma cells.

[Lung] Researchers investigated β2-adrenoceptor-mediated signaling pathways involved in the production of two pro-inflammatory cytokines, interleukin (IL)-6 and IL-8, in 16HBE14o- human bronchial epithelia.

[Cell Death & Disease] The authors investigated a previously unrecognized role for ferroptosis in psoriasis, where ferroptosis was mediated by lipid peroxidation and iron overload. They found that ferrostatin-1 blocked inflammatory responses in vitro and in vivo, which reduced cytokine production.

[Molecular Neurobiology] Researchers applied the recently established mixed neuroglial primary cell culture of the rat superficial dorsal horn (SDH) to investigate effects of adipose mesenchymal stem cells on the inflammatory response of SDH cells.

[EMBO Reports] Using a single somatic copy number alteration score inclusive of whole-chromosome, chromosome arm, and focal alterations in a pan-cancer analysis of 9,375 samples in The Cancer Genome Atlas database, scientists found an inverse correlation with a cytotoxicity score across disease stages.

[Nature Communications] Scientists showed that chemotherapy-induced anti-cancer immunity was suppressed by the tumor microenvironment through production of the cytokine IL-6.