IL-6

[Acta Pharmacologica Sinica] Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.

[Scientific Reports] Investigators reported Mangiferin functionalized gold nanoparticulate agent and its immunomodulatory characteristics in treating prostate cancer.

[Nature Communications] Visceral adipose-derived factors promoted vasculogenesis and the onset of metastatic dissemination by activation of STAT3, which inhibited miR-200a and enhanced ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.

[Mucosal Immunology] Through transcriptomics analysis, we observed that Entamoeba histolytica infection was associated with increased expression of IL-33 mRNA in both the human and murine colon.

[Hepatology] Researchers investigated whether and how cancer-associated fibroblasts (CAFs) regulated myeloid-derived suppressor cells function to enhance cancer stemness, the driving force of the cancer aggressiveness and chemotherapy refractoriness, in highly desmoplastic intrahepatic cholangiocarcinoma.