AEG-1 Silencing Attenuates M2-Polarization of Glioma-Associated Microglia/Macrophages and Sensitizes Glioma Cells to Temozolomide

Researchers showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.
[Scientific Reports]
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Redundant Cytokine Requirement for Intestinal Microbiota-Induced Th17 Cell Differentiation in Draining Lymph Nodes

Scientists showed that intestine-draining mesenteric lymph nodes, not intestine proper, were the dominant site of segmented filamentous bacteria-induced intestinal Th17 cell differentiation.
[Cell Reports]
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Amygdalin Attenuates Airway Epithelium Apoptosis, Inflammation, and Epithelial-Mesenchymal Transition through Restraining the TLR4/NF-κB Signaling Pathway on LPS-Treated BEAS-2B Bronchial Epithelial Cells

Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.
[International Archives of Allergy and Immunology]
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Particulate Matter-Induced Atmospheric Skin Aging Is Aggravated by UVA and Inhibited by a Topical L-Ascorbic Acid Compound

Scientists analyzed whether ultraviolet A aggravated the particulate matter-induced inflammatory cascade, which contributed to the aging of skin-derived cells.
[Photodermatology Photoimmunology & Photomedicine]
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E-Cigarette Fluids and Aerosol Residues Cause Oxidative Stress and an Inflammatory Response in Human Keratinocytes and 3D Skin Models

Investigators evaluated the effects of electronic cigarette (EC) refill fluids and EC exhaled aerosol residue on cultured human keratinocytes and MatTek EpiDerm, a 3D air liquid interface human skin model.
[Toxicology in Vitro]
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Ethyl Ferulate Protects against Lipopolysaccharide-Induced Acute Lung Injury by Activating AMPK/Nrf2 Signaling Pathway

Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.
[Acta Pharmacologica Sinica]
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Green Nanotechnology of MGF-AuNPs for Immunomodulatory Intervention in Prostate Cancer Therapy

Investigators reported Mangiferin functionalized gold nanoparticulate agent and its immunomodulatory characteristics in treating prostate cancer.
[Scientific Reports]
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Adipose Stem Cell Niche Reprograms the Colorectal Cancer Stem Cell Metastatic Machinery

Visceral adipose-derived factors promoted vasculogenesis and the onset of metastatic dissemination by activation of STAT3, which inhibited miR-200a and enhanced ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
[Nature Communications]
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The IL-33-ILC2 Pathway Protects from Amebic Colitis

Through transcriptomics analysis, we observed that Entamoeba histolytica infection was associated with increased expression of IL-33 mRNA in both the human and murine colon.
[Mucosal Immunology]
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Melatonin as an Immunomodulator in Children with Down Syndrome

Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.
[Pediatric Research]
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CAFs Shape Myeloid-Derived Suppressor Cells to Promote Stemness of Intrahepatic Cholangiocarcinoma via 5-Lipoxygenase

Researchers investigated whether and how cancer-associated fibroblasts (CAFs) regulated myeloid-derived suppressor cells function to enhance cancer stemness, the driving force of the cancer aggressiveness and chemotherapy refractoriness, in highly desmoplastic intrahepatic cholangiocarcinoma.
[Hepatology]
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