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IL-6

CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-κB Signaling Pathway

[Inflammation] Investigators found that circular RNA OAS3 (circOAS3) expression was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes.

Triglyceride Breakdown from Lipid Droplets Regulates the Inflammatory Response in Macrophages

[Proceedings of the National Academy of Sciences of the United States of America] The authors identified the importance of the hypoxia-inducible lipid droplet–associated protein and the intracellular adipose triglyceride lipase in the regulation of lipid accumulation and breakdown in inflammatory macrophages.

Skeletal Muscle-Specific Overexpression of miR-486 Limits Mammary Tumor-Induced Skeletal Muscle Functional Limitations

[Molecular Therapy-Nucleic Acids] To determine whether skeletal muscle miR-486 was functionally similar in dystrophies and cancer, the authors performed functional limitations and biochemical studies of skeletal muscles of MMTV-Neu mice that mimicked HER2+ breast cancer and MMTV-PyMT mice that mimicked luminal subtype B breast cancer.

Catalpol Protects AC16 Cells from Hypoxia/Reoxygenation Injury by Regulating the miR-22-3p/DPP4 Axis

[Journal of Biochemical and Molecular Toxicology] Catalpol promoted the viability and reduced cell apoptosis of human cardiomyocyte AC16 cells and repressed the release of inflammatory cytokines TNF-α, IL-6, and IL-1β, while inhibiting the leakage of myocardial injury markers lactate dehydrogenase and creatine kinase.

Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways

[Frontiers in Molecular Biosciences] In vitro genetic ablation of golgi phosphoprotein 3 (GOLPH3) was performed using small interfering RNA transfection, and a stably overexpressed GOLPH3 colon cancer cell line was constructed using the lentivirus system.

IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment

[Frontiers in Oncology] The authors cover the current biological understanding of the interleukin-6 (IL-6) signaling pathway and its impact on breast cancer metastasis, as well as, therapeutic interventions that target components of the IL-6 pathway.

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