IL-1β decreased the expression of the LXR target gene ABCA1 in cultured intestinal epithelial cells. The synthetic LXR agonist GW3965 led to a decreased nuclear positivity of the p65 subunit of nuclear factor kappa B, a phosphorylation ratio of the p44-42 mitogen-activated protein kinase, and the expression of CCL-28 and IL-8 in IL-1β-stimulated Caco-2 cells.
[Inflammatory Bowel Diseases]
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Miranda-Bautista, J., Rodríguez-Feo, J. A., Puerto, M., López-Cauce, B., Lara, J. M., González-Novo, R., Martín-Hernández, D., Ferreiro-Iglesias, R., Bañares, R., & Menchén, L. (2021). Liver X Receptor Exerts Anti-Inflammatory Effects in Colonic Epithelial Cells via ABCA1 and Its Expression Is Decreased in Human and Experimental Inflammatory Bowel Disease. Inflammatory Bowel Diseases, izab034. https://doi.org/10.1093/ibd/izab034 Cite
Scientists examined longitudinal plasma samples from hospitalized COVID-19 patients with differential clinical outcome.
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Tang, J., Ravichandran, S., Lee, Y., Grubbs, G., Coyle, E. M., Klenow, L., Genser, H., Golding, H., & Khurana, S. (2021). Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients. Nature Communications, 12(1), 1221. https://doi.org/10.1038/s41467-021-21463-2 Cite
Researchers hypothesized that HIV induced the basal stem/progenitor cells to express inflammatory mediators that contributed to the pathogenesis of emphysema.
With a view towards harnessing the therapeutic potential of canine (c)MSCs as modulators of inflammation and the immune response, and to avoid the issues of the variable quality and quantity of harvested cMSCs, scientists examined the immunomodulatory properties of cMSCs derived from canine induced pluripotent stem cells, and compared them to cMSCs harvested from adipose tissue and bone marrow.
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Shahsavari, A., Weeratunga, P., Ovchinnikov, D. A., & Whitworth, D. J. (2021). Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells. Scientific Reports, 11(1), 3486. https://doi.org/10.1038/s41598-021-82856-3 Cite
In this Phase I clinical trial, researchers present the safety, feasibility, and tolerability of the multiple infusions of high dose MSCs, which originated from the placenta and umbilical cord, in critically ill COVID-19-induced acute respiratory distress syndrome (ARDS) patients.
[Stem Cell Research & Therapy]
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Hashemian, S.-M. R., Aliannejad, R., Zarrabi, M., Soleimani, M., Vosough, M., Hosseini, S.-E., Hossieni, H., Keshel, S. H., Naderpour, Z., Hajizadeh-Saffar, E., Shajareh, E., Jamaati, H., Soufi-Zomorrod, M., Khavandgar, N., Alemi, H., Karimi, A., Pak, N., Rouzbahani, N. H., Nouri, M., … Baharvand, H. (2021). Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series. Stem Cell Research & Therapy, 12(1), 91. https://doi.org/10.1186/s13287-021-02165-4 Cite
The authors stimulated freshly isolated umbilical blood mononuclear cells with lysates of E. faecalis, S. agalacticae, and S. aureus collected from pregnant women in preterm labor.
[International Journal of Molecular Sciences]
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Scientists explored the role of the immune cell-secreted serine protease, granzyme B, in pemphigoid disease pathogenesis using three independent murine models. In all models, granzyme B knockout or topical pharmacological inhibition significantly reduces total blistering area compared to controls.
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Hiroyasu, S., Zeglinski, M. R., Zhao, H., Pawluk, M. A., Turner, C. T., Kasprick, A., Tateishi, C., Nishie, W., Burleigh, A., Lennox, P. A., Van Laeken, N., Carr, N. J., Petersen, F., Crawford, R. I., Shimizu, H., Tsuruta, D., Ludwig, R. J., & Granville, D. J. (2021). Granzyme B inhibition reduces disease severity in autoimmune blistering diseases. Nature Communications, 12(1), 302. https://doi.org/10.1038/s41467-020-20604-3 Cite
Proteomics analysis of octenidine dihydrochloride-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines and matrix-metalloproteinases when compared to controls.
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Seiser, S., Janker, L., Zila, N., Mildner, M., Rakita, A., Matiasek, J., Bileck, A., Gerner, C., Paulitschke, V., & Elbe-Bürger, A. (2021). Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin. Scientific Reports, 11(1), 32. https://doi.org/10.1038/s41598-020-79378-9 Cite
IL-8 has been reported to favor cancer progression and metastases via different mechanisms, including pro-angiogenesis and maintenance of cancer stem cells, but its ability to attract and functionally modulate neutrophils and macrophages arguably may be the most important factors.
[Clinical Cancer Research]
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Teijeira, A., Garasa, S., Ochoa, M. C., Esparza, M. V., Olivera, I., Cirella, A., Eguren-Santamaria, I., Berraondo, P., Schalper, K. A., Andrea, C. E. de, Sanmamed, M. F., & Melero, I. (2020). Interleukin-8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-1319 Cite
Using normal and malignant lymphocytes from humans, and the phosphodiesterase 4b knockout mouse, scientists found that cAMP induced PD-L1 transcription and protein expression.
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Scientists explored the investigative mechanism of salidroside on LPS-induced acute lung injury/acute respiratory distress syndrome.
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