Tumor-Associated Neutrophils Orchestrate Intratumoural IL-8-Driven Immune Evasion through Jagged2 Activation in Ovarian Cancer

Scientists characterized tumor associated neutrophils (TANs) using flow cytometric analysis and immunofluorescence analysis. The prognostic merit of TANs in epithelial ovarian cancer was evaluated using cox regression analysis.
[British Journal of Cancer]
Abstract

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Aesculetin Attenuates Alveolar Injury and Fibrosis Induced by Close Contact of Alveolar Epithelial Cells with Blood-Derived Macrophages via IL-8 Signaling

Human alveolar epithelial A549 cells were cultured for 24 hours in conditioned media of THP-1 monocyte-derived macrophages with 1–20 μM aesculetin.
[International Journal of Molecular Sciences]
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TNF-α Controls Lipocalin-2 Expression in PC-3 Prostate Cancer Cells

Researchers showed for the first time that LCN2 mRNA and protein expression were strongly inducible by TNF-α in the highly metastatic human PCa cell line PC-3.
[Cytokine]
AbstractGraphical Abstract

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Placental Hypoxia-Induced Alterations in Vascular Function, Morphology, and Endothelial Barrier Integrity

Placental villous explants of noncomplicated placentae and BeWo cells were subjected to hypoxia. The effect of placental hypoxic-conditioned medium on intraluminal-induced contraction and endothelial barrier integrity in chorionic arteries was investigated using pressure myography.
[Hypertension Research]
Vangrieken, P., Remels, A. H. V., Al-Nasiry, S., Bast, A., Janssen, G. M. J., von Rango, U., Vroomans, D., Pinckers, Y. C. W., van Schooten, F. J., & Schiffers, P. M. H. (2020). Placental hypoxia-induced alterations in vascular function, morphology, and endothelial barrier integrity. Hypertension Research, 1–14. https://doi.org/10.1038/s41440-020-0528-8 Cite
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Alteration of Immunophenotype of Human Macrophages and Monocytes after Exposure to Cigarette Smoke

Using human monocyte-derived macrophages (MDMs) from healthy donors, researchers found that cigarette smoke exposure was not associated with significant changes in the production of pro inflammatory cytokines by MDMs.
[Scientific Reports]
da Silva, C. O., Gicquel, T., Daniel, Y., Bártholo, T., Vène, E., Loyer, P., Pôrto, L. C., Lagente, V., & Victoni, T. (2020). Alteration of immunophenotype of human macrophages and monocytes after exposure to cigarette smoke. Scientific Reports, 10(1), 12796. https://doi.org/10.1038/s41598-020-68753-1 Cite
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Blocking Endothelial Apoptosis Revascularises the Retina in a Model of Ischemic Retinopathy

Researchers investigated the role of endothelial cell (EC) apoptosis in retinal hypoxia using a mouse model of ischemic retinopathy, in which vessel closure and EC apoptosis caused capillary regression and retinal ischemia followed by neovascularisation.
[Journal of Clinical investigation]
AbstractGraphical Abstract

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