Salidroside Regulates Inflammatory Pathway of Alveolar Macrophages by Influencing the Secretion of miRNA-146a Exosomes by Lung Epithelial Cells

Scientists explored the investigative mechanism of salidroside on LPS-induced acute lung injury/acute respiratory distress syndrome.
[Scientific Reports]
Zheng, L., Su, J., Zhang, Z., Jiang, L., Wei, J., Xu, X., & Lv, S. (2020). Salidroside regulates inflammatory pathway of alveolar macrophages by influencing the secretion of miRNA-146a exosomes by lung epithelial cells. Scientific Reports, 10(1), 20750. https://doi.org/10.1038/s41598-020-77448-6 Cite
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Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-Forming Cells

CXCR1 and CXCR2 were not detected on several clones of cord blood- endothelial colony-forming cell using different antibodies available, in contrast to well-known positive cells.
[Stem Cell Reviews and Reports]
Blandinières, A., Hong, X., Philippe, A., Bièche, I., Vacher, S., Rossi, E., Detriche, G., Gendron, N., Gaussem, P., Guerin, C. L., Melero-Martin, J. M., & Smadja, D. M. (2020). Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10081-y Cite
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A Notch-Dependent Inflammatory Feedback Circuit between Macrophages and Cancer Cells Regulates Pancreatic Cancer Metastasis

Researchers identified a Notch-dependent feedback circuit between pancreatic cancer cells and macrophages which contributed to PDAC metastasis. In this circuit, miR-124 regulated Notch signaling in cancer cells by directly targeting the Notch ligand Jagged 1.
[Cancer Research]
Geng, Y., Fan, J., Chen, L., Zhang, C., Qu, C., Qian, L., Chen, K., Meng, Z., Chen, Z., & Wang, P. (2020). A Notch-dependent inflammatory feedback circuit between macrophages and cancer cells regulates pancreatic cancer metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0256 Cite
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Paracoccidioides brasiliensis Downmodulates α3 Integrin Levels in Human Lung Epithelial Cells in a TLR2-Dependent Manner

Scientists showed that, after 24 hour post-infection with P. brasiliensis, A549 lung epithelial cells presented higher TLR2 levels, which is important for IL-8 secretion.
[Scientific Reports]
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Galectin-7 Downregulation in Lesional Keratinocytes Contributes to Enhanced IL-17A Signaling and Skin Pathology in Psoriasis

Scientists found that the expression of galectin-7 was reduced in the skin lesions of patients with psoriasis. IL-17A and TNF-α, two cytokines intimately involved in the development of psoriatic lesions, suppressed galectin-7 expression in human primary keratinocytes and the immortalized human keratinocyte cell line HaCaT.
[Journal of Clinical Investigation]
Chen, H.-L., Lo, C.-H., Huang, C.-C., Lu, M.-P., Hu, P.-Y., Chen, C.-S., Chueh, D.-Y., Chen, P., Lin, T.-N., Lo, Y.-H., Hsiao, Y.-P., Hsu, D. K., & Liu, F.-T. (2020). Galectin‐7 downregulation in lesional keratinocytes contributes to enhanced IL‐17A signaling and skin pathology in psoriasis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI130740 Cite
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Elimination of Nf-kB Signaling in Vimentin+ Stromal Cells Attenuates Tumorigenesis in a Mouse Model of Barrett Esophagus

To analyze the effect of NF-kB signaling in myofibroblasts (MFs), researchers crossed L2-IL-1B mice to tamoxifen inducible Vim-Cre mice and floxed RelA mice to specifically eliminate NF-kB signaling in MF. The interaction of epithelial cells and stromal cells was further analyzed in mouse Barrett Esophagus organoids and patient-derived human organoids.
[Carcinogenesis]
Anand, A., Fang, H.-Y., Mohammad Shahi, D., Ingermann, J., Baumeister, T., Strangmann, J., Wang, T. C., & Quante, M. (n.d.). Elimination of Nf-kB signaling in Vimentin+ stromal cells attenuates tumorigenesis in a mouse model of Barrett Esophagus. Carcinogenesis. https://doi.org/10.1093/carcin/bgaa109 Cite
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Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury

Endothelial cells were exposed to high levels of the cholesterol oxidation product, 7-ketocholesterol, in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation.
[NeuroMolecular Medicine]
Koh, S. S., Ooi, S. C.-Y., Lui, N. M.-Y., Qiong, C., Ho, L. T.-Y., Cheah, I. K.-M., Halliwell, B., Herr, D. R., & Ong, W.-Y. (2020). Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury. NeuroMolecular Medicine. https://doi.org/10.1007/s12017-020-08620-4 Cite
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Interleukin-8 as a Candidate for Thymoma Identification and Recurrence Surveillance

Scientists identified interleukin-8 as a biomarker for auxiliary diagnosis of thymoma. They found that IL-8 levels in naïve T cells were markedly elevated in patients with thymoma compared to those with other thymic tumors.
[Nature Communications]
Gao, S., Jiang, J., Jin, C., Gao, J., Xiong, D., Yang, P., Cui, S., Yang, W., Leng, Q., Dong, J., Chen, G., Liu, J., Wang, L., Ke, A., Wang, H., & Ding, J. (2020). Interleukin-8 as a candidate for thymoma identification and recurrence surveillance. Nature Communications, 11(1), 4881. https://doi.org/10.1038/s41467-020-18697-x Cite
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6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling

Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.
[Molecules]
Liu, R., Choi, H. S., Kim, S.-L., Kim, J.-H., Yun, B.-S., & Lee, D.-S. (2020). 6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling. Molecules, 25(19), 4374. https://doi.org/10.3390/molecules25194374 Cite
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Interleukin-8 as a Candidate for Thymoma Identification and Recurrence Surveillance

Scientists identified interleukin-8 as a biomarker for auxiliary diagnosis of thymoma. They found that IL-8 levels in naïve T cells were markedly elevated in patients with thymoma compared to those with other thymic tumors.
[Nature Communications]
Gao, S., Jiang, J., Jin, C., Gao, J., Xiong, D., Yang, P., Cui, S., Yang, W., Leng, Q., Dong, J., Chen, G., Liu, J., Wang, L., Ke, A., Wang, H., & Ding, J. (2020). Interleukin-8 as a candidate for thymoma identification and recurrence surveillance. Nature Communications, 11(1), 4881. https://doi.org/10.1038/s41467-020-18697-x Cite
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Neutrophil Elastase Promotes Macrophage Cell Adhesion and Cytokine Production through the Integrin-Src Kinases Pathway

The authors demonstrated that monocyte-derived Mɸ exposed to neutrophil elastas releases active matrix metalloproteinases, increased expression of pro-inflammatory cytokines TNFα, IL-1β, and IL-8, and reduced capacity to phagocytose bacteria.
[Scientific Reports]
Krotova, K., Khodayari, N., Oshins, R., Aslanidi, G., & Brantly, M. L. (2020). Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway. Scientific Reports, 10(1), 15874. https://doi.org/10.1038/s41598-020-72667-3 Cite
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