Mesenchymal Stromal Cell Therapy in Novel Porcine Model of Diffuse Liver Damage Induced by Repeated Biliary Obstruction

Researchers evaluated the effect of allogenic mesenchymal stem cell transplantation in a large animal model of repeated biliary obstruction followed by partial hepatectomy.
[International Journal of Molecular Sciences]
Vištejnová, L., Liška, V., Kumar, A., Křečková, J., Vyčítal, O., Brůha, J., Beneš, J., Kolinko, Y., Blassová, T., Tonar, Z., Brychtová, M., Karlíková, M., Racek, J., Mírka, H., Hošek, P., Lysák, D., & Králíčková, M. (2021). Mesenchymal Stromal Cell Therapy in Novel Porcine Model of Diffuse Liver Damage Induced by Repeated Biliary Obstruction. International Journal of Molecular Sciences, 22(9), 4304. https://doi.org/10.3390/ijms22094304 Cite
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Paracrine Interleukin-8 Affects Mesenchymal Stem Cells through the Akt Pathway and Enhances Human Umbilical Vein Endothelial Cell Proliferation and Migration

Cultured human umbilical vein endothelial cells (HUVECs) were cultured in bone marrow mesenchymal stem cell conditioned medium
[Bioscience Reports]
wang, L., Li, Y., Zhang, X., Liu, N., Shen, S., Sun, S., Jiang, Y., Li, P., Jin, H., & Shen, L. (2021). Paracrine Interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration. Bioscience Reports, BSR20210198. https://doi.org/10.1042/BSR20210198 Cite
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Cromolyn Inhibits the Secretion of Inflammatory Cytokines by Human Microglia (HMC3)

To better understand the mechanistic effect cromolyn has in slowing down or halting the neuroinflammatory response associated with Alzheimer’s Disease progression, the authors tested the effect of cromolyn to dampen the inflammatory response in the human HMC3 microglia cell line.
[Scientific Reports]
Wang, Y.-J., Monteagudo, A., Downey, M. A., Ashton-Rickardt, P. G., & Elmaleh, D. R. (2021). Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3). Scientific Reports, 11(1), 8054. https://doi.org/10.1038/s41598-021-85702-8 Cite
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Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.
[International Journal of Molecular Sciences]
Mato-Basalo, R., Morente-López, M., Arntz, O. J., van de Loo, F. A. J., Fafián-Labora, J., & Arufe, M. C. (2021). Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells. International Journal of Molecular Sciences, 22(7), 3367. https://doi.org/10.3390/ijms22073367 Cite
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CCL8 Mediates Crosstalk between Endothelial Colony Forming Cells and Triple-Negative Breast Cancer Cells through IL-8, Aggravating Invasion and Tumorigenicity

Using an indirect co-culture system, scientists showed that co-culture increased the invasive and migratory phenotypes of both MDA-MB-231 TNBC cells and endothelial colony-forming cells.
[Oncogene]
CCL8 mediates crosstalk between endothelial colony forming cells and triple-negative breast cancer cells through IL-8, aggravating invasion and tumorigenicity | Oncogene. (n.d.). Retrieved April 8, 2021, from https://www.nature.com/articles/s41388-021-01758-w Cite
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Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

HUVECs and human lung microvascular endothelial cells incubated with human sickle cell plasma had significant increases in pro-inflammatory IL-8, IL-6, and soluble VCAM-1 secretion compared to endothelial cells incubated with normal plasma.
[Frontiers in Immunology]
Zhang, P., Nguyen, J., Abdulla, F., Nelson, A. T., Beckman, J. D., Vercellotti, G. M., & Belcher, J. D. (2021). Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.632709 Cite
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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Chondrogenic and BMP-4 Primings Confer Osteogenesis Potential to Human Cord Blood Mesenchymal Stromal Cells Delivered with Biphasic Calcium Phosphate Ceramics

The authors evaluated the in vitro osteogenic potential of unprimed, osteogenically primed, or chondrogenically primed cord blood MSCs and bone marrow MSCs and their in vivo bone forming capacity following ectopic implantation on biphasic calcium phosphate ceramics in nude mice.
[Scientific Reports]
Brennan, M. Á., Barilani, M., Rusconi, F., de Lima, J., Vidal, L., Lavazza, C., Lazzari, L., Giordano, R., & Layrolle, P. (2021). Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics. Scientific Reports, 11(1), 6751. https://doi.org/10.1038/s41598-021-86147-9 Cite
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The Role of PKM2 Nuclear Translocation in the Constant Activation of the NF-κB Signaling Pathway in Cancer-Associated Fibroblasts

The authors showed that mesenchymal stem cells differentiated into cancer-associated fibroblasts, induced by the exosomes derived from gastric cancer cells.
[Cell Death & Disease]
Gu, J., Li, X., Zhao, L., Yang, Y., Xue, C., Gao, Y., Li, J., Han, Q., Sun, Z., Bai, C., & Zhao, R. C. (2021). The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03579-x Cite
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Olodaterol Exerts Anti-inflammatory Effects on COPD Airway Epithelial Cells

Human bronchial epithelial brushing from patients with and without COPD were cultured into air–liquid interface cultures and treated with or without olodaterol and respiratory syncytial virus infection to examine the effect on markers of inflammation including interleukin-8 and mucus secretion.
[Respiratory Research]
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Liver X Receptor Exerts Anti-Inflammatory Effects in Colonic Epithelial Cells via ABCA1 and Its Expression Is Decreased in Human and Experimental Inflammatory Bowel Disease

IL-1β decreased the expression of the LXR target gene ABCA1 in cultured intestinal epithelial cells. The synthetic LXR agonist GW3965 led to a decreased nuclear positivity of the p65 subunit of nuclear factor kappa B, a phosphorylation ratio of the p44-42 mitogen-activated protein kinase, and the expression of CCL-28 and IL-8 in IL-1β-stimulated Caco-2 cells.
[Inflammatory Bowel Diseases]
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