IL-8

[Histochemistry and Cell Biology] Scientists focused on potential differences in the activity of exosomes produced by melanoma cells towards melanoma-associated fibroblasts and normal dermal fibroblasts. They demonstrated that melanoma-produced exosomes significantly stimulated the tumor-promoting proinflammatory activity of cancer-associated fibroblasts.

[Oncogenesis] Researchers identified androgen-deprivation therapy-mediated upregulation of transcription factor 7 like 1 (TCF7L1), which increased the cytokine response and enhanced neuroendocrine differentiation of prostate cancer through interleukin-8/C-X-C motif chemokine receptor type 2 signaling activation.

[Biomedicine & Pharmacotherapy] Researchers evaluated the effect of methoxy-derivatives of 2’-hydroxychalcones: 2’-hydroxy-3”-methoxychalcone, 2’-hydroxy-2”-methoxychalcone and 2’-hydroxy-4”-metoxychalcone at the concentrations of 10 µM and 25 µM on the release of IL-8, MIF, VCAM-1, ICAM-1 by colon cancer SW480 and SW620 cell lines.

[Scientific Reports] The authors sampled 175 hepatocellular carcinoma, 117 cirrhotic and 165 non-cirrhotic controls from a prospective cohort study of chronically hepatitis B virus-infected individuals to assess immunologic markers in relation to liver disease.

[Oxidative Medicine and Cellular Longevity] Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus.

[PLoS One] Investigators established a model for interleukin 1β (IL-1β)-induced dermatitis and investigated mitogen-activated protein kinase signaling pathways in IL-1β-induced interleukin 8 (IL-8) expression.