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IL-8

PERK Signaling through C/EBPδ Contributes to ER Stress-Induced Expression of Immunomodulatory and Tumor Promoting Chemokines by Cancer Cells

[Cell Death & Disease] The PERK pathway inhibits global protein synthesis while allowing translation of specific mRNAs, such as the ATF4 transcription factor.

β2-Adrenoceptor Activation Stimulates IL-6 Production via PKA, ERK1/2, Src, and Beta-Arrestin2 Signaling Pathways in Human Bronchial Epithelia

[Lung] Researchers investigated β2-adrenoceptor-mediated signaling pathways involved in the production of two pro-inflammatory cytokines, interleukin (IL)-6 and IL-8, in 16HBE14o- human bronchial epithelia.

Bioscaffold Stiffness Mediates Aerosolized Nanoparticle Uptake in Lung Epithelial Cells

[ACS Applied Materials & interfaces] The human lung A549 cells cultured on both stiff and soft polyurethane soft dendritic colloids membranes were found to be viable, capable of supporting the air–liquid interface cell culture, and maintained barrier integrity.

Effects of Electrical Stimulation on Human Skin Keratinocyte Growth and the Secretion of Cytokines and Growth Factors

[Biomedical Materials] The authors demonstrated that the proliferation of keratinocytes and their secretion of cytokines and growth factors could be activated through appropriate electrical stimulation to benefit skin wound healing.

DNAM-1/CD226 Is Functionally Expressed on Acute Myeloid Leukemia (AML) Cells and Is Associated with Favorable Prognosis

[Scientific Reports] Investigators analyzed expression of DNAM-1 in leukemic cells of AML patients. Interaction of DNAM-1 with its ligands CD112 and CD155 induced release of the immunomodulatory cytokines IL-6, IL-8 IL-10 and TNF-α by AML cells and DNAM-1 expression correlated with a more differentiated phenotype.

Cobalt-Induced Oxidative Stress Contributes to Alveolar/Bronchiolar Carcinogenesis in B6C3F1/N Mice

[Archives of Toxicology] In vitro studies, such as DMPO immune-spin trapping assay, and dihydroethidium fluorescence assay on A549 and BEAS-2B cells demonstrated increased oxidative stress due to cobalt exposure.

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