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ITGAV

Histone Methyltransferase KMT2C Plays an Oncogenic Role in Prostate Cancer

[Journal of Cancer Research and Clinical Oncology] The authors assessed the function of KMT2C in prostate cancer cell proliferation, colony formation, and migration.

Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer

[Genes] The authors found that homeobox A11 antisense RNA (HOXA11-AS), a highly expressed long noncoding RNA in cell lines derived from prostate cancer bone metastases, promoted the cell invasion and proliferation of PC3 prostate cancer cells.

Breast Tumor Cell Invasion and Pro-invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides

[Cancers] In three dimensional organotypic assays, peptide-exposed telomerase immortalised fibroblasts and primary cancer-associated fibroblasts from breast carcinoma patients both exhibited a markedly reduced pro-invasive ability of either HT1080 fibrosarcoma or MDA-MB-231 mammary carcinoma cells, respectively.

The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

[Stem Cell Reports] Scientists showed that Itgav deletion results in increased frequency of phenotypic hematopoietic stem cells in fetal liver due to faster proliferation.

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