In vivo and in vitro experiments showed that N-docosahexaenoylethanolamine: improved indicators of anxiety and long-term memory; inhibited the pro-inflammatory microglial cells activity; decreased the level of pro-inflammatory cytokines/ROS/NO/nitrites; increased CD206 and superoxide dismutase production.
Ponomarenko, A. I., Tyrtyshnaia, A. A., Pislyagin, E. A., Dyuizen, I. V., Sultanov, R. M., & Manzhulo, I. V. (2021). N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Scientific Reports, 11(1), 756. https://doi.org/10.1038/s41598-020-80818-9Cite
Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.
Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3Cite
Lee, S.-H., Kang, H.-Y., Kim, J.-H., & Park, D.-H. (2020). Mannitol Augments the Effects of Systemical Stem Cell Transplantation without Increasing Cell Migration in a Stroke Animal Model. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-020-00293-1Cite