Iba-1

[Stem Cells International] Investigators manufactured neprilysin gene-enhanced human umbilical cord-derived MSCs and intravenously transplanted them in Aβ1-42-injected Alzheimer’s disease animal models.

[Scientific Reports] In vivo and in vitro experiments showed that N-docosahexaenoylethanolamine: improved indicators of anxiety and long-term memory; inhibited the pro-inflammatory microglial cells activity; decreased the level of pro-inflammatory cytokines/ROS/NO/nitrites; increased CD206 and superoxide dismutase production.

[Life Sciences] Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.

[Pharmacological Research] MSCs-extracellular vesicles treatment remarkably restored synaptic reorganization and up-regulated synaptic protein expression post-hypoxia-ischemic, concomitant with reducing osteopontin levels.

[Scientific Reports] Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.

[Journal of Tissue Engineering and Regenerative Medicine] Researchers elucidated the neuroprotective effects of a combination of mannitol pretreatment and stem cell transplantation on stroke-induced neural injury.