KRAS

[Cell Death & Disease] Researchers investigated the role of the CDK inhibitor p27kip1 in the response to the selective CDK4/6-inhibitor Palbociclib, in colorectal cancer.

[Science Advances] Scientists reported that RGX-202, an oral small-molecule SLC6A8 transporter inhibitor, robustly inhibited creatine import in vitro and in vivo, reduced intracellular phosphocreatine and ATP levels, and induced tumor apoptosis.

[Molecular Cancer Research] Researchers examined the role of DKK3 by overexpression and knockdown and discovered that DKK3 suppressed Wnt signaling in APC-null murine colonic organoids and human colon cancer cells despite the presence of downstream activating mutations in the Wnt pathway.

[Modern Pathology] In this review, scientists address the state of PD-L1 testing in lung cancer, the role for tumor mutation burden as a predictive biomarker

[Annals of Hematology] Scientists evaluated the efficacy and safety of venetoclax plus azacitidine and donor lymphocyte infusion in treating patients with relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation.

[Cell Reports Methods] The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.