Cancer Immunotherapy: It’s Time to Better Predict Patients’ Response

The authors critically discuss current knowledge regarding predictive biomarkers for checkpoint inhibitor-based immunotherapy, highlight the missing/unclear links and emphasise the importance of characterising each neoplasm and its microenvironment in order to better guide the course of treatment.
[British Journal of Cancer]
Pilard, C., Ancion, M., Delvenne, P., Jerusalem, G., Hubert, P., & Herfs, M. (2021). Cancer immunotherapy: it’s time to better predict patients’ response. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-021-01413-x Cite
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Expression of Inhibitory Receptors on T and NK Cells Defines Immunological Phenotypes of HCV Patients with Advanced Liver Fibrosis.

Investigators found that advanced fibrosis patients had higher frequencies of >3 inhibitory receptor co-expression on NK cells.
[iScience]
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Vaginal Microbiota, Genital Inflammation, and Neoplasia Impact Immune Checkpoint Protein Profiles in the Cervicovaginal Microenvironment

The authors demonstrated that immune checkpoint molecules could be measured in cervicovaginal lavages. They identified CD40, CD27, and TIM-3 to specifically discriminate cervical cancer from other groups and CD40, CD28, and TLR2 to positively correlate to genital inflammation.
[npj Precision Oncology]
Łaniewski, P., Cui, H., Roe, D. J., Chase, D. M., & Herbst-Kralovetz, M. M. (2020). Vaginal microbiota, genital inflammation, and neoplasia impact immune checkpoint protein profiles in the cervicovaginal microenvironment. Npj Precision Oncology, 4(1), 1–9. https://doi.org/10.1038/s41698-020-0126-x Cite
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