Lgr5

[Nature Cell Biology] Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.

[Cell Stem Cell] Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.

[British Journal of Cancer] Scientists explicated a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer.

[Biofabrication] Investigators presented a method to model the peristalsis for human colon tumor organoids on a microfluidic chip.

[Science Advances] Researchers reported that cGAS-STING–dependent type 1 interferon response drove intestinal regeneration and animal recovery from radiation injury.

[Cell Stem Cell] The authors showed that SATB2, a colon-restricted chromatin factor, singularly preserved LGR5+ adult colonic stem cell and epithelial identity in mice and humans.