Lgr5

[Scientific Reports] Scientists investigated LGR5 expression in normal, benign, and malignant lesions of the human breast using RNA in situ hybridization, and suggested that LGR5 marked facultative stem cells that were involved in post injury regeneration instead of homeostatic stem cells.

[Tissue and Cell] A 3D thermo-reversible gelation polymer culture system was established for organoid culture of mouse fallopian tube epithelial stem cells without cell isolation.

[Biomedicine & Pharmacotherapy] Anti-carcinogenic properties of amorphous curcumin, a compound with improved solubility and bioavailability, were evaluated against human colorectal cancer organoids.

[International Journal of Biochemistry & Cell Biology] An ovarian cancer cell line, PEO4, was initially reprogrammed into induced pluripotent stem cells using the classical four factors OCT4, SOX2, KLF4 and MYC using lentivirus transduction.

[International Journal of Biochemistry & Cell Biology] An ovarian cancer cell line, PEO4, was reprogrammed into iPSCs using the classical four factors OCT4, SOX2, KLF4 and MYC (OSKM) using lentivirus transduction.

[Oncogene] Researchers found that miR-22 facilitated β-catenin stabilization through directly repressing citrullinase PAD2.