Lgr5

[Stem Cell Research & Therapy] Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.

[Carcinogenesis] The expression of Inhibitor of DNA binding and cell differentiation 4 (ID4), but not other ID family proteins, was enriched in LGR5-high colon cancer stem cells.

[Scandinavian Journal of Gastroenterology] The authors found that LINGO3 was broadly expressed on human enterocytes and sparsely on discrete cells within the crypt niche, that contained sintestinal stem cells.

[Molecular Cell] Disruption of the ZMYND8-dependent MVA pathway greatly restricted the self-renewal capacity of Lgr5+ intestinal stem cells and intestinal tumorigenesis.

[Cell Reports] Scientists provide genetic evidence that mTOR activation promotes proliferation and inhibits differentiation of Lgr5+ gastric epithelial progenitors in gastric homeostasis and tumorigenesis.

[Stem Cell Reports] Myh9 deletion disturbs cell junctions and impairs intestinal lumen barrier integrity, promoting the necroptosis of epithelial cells.