Lgr5

[Cellular and Molecular Gastroenterology and Hepatology] Investigators analyzed Lgr5-Cre; APCmin; HER2V777LTg mice by morphologic and gene expression assays on intestinal sections and organoids derived from the epithelium.

[iScience] Scientists report a Wnt ligand, Dickkopf-2 (DKK2) was essential for developing colorectal cancer stemness. Genetic depletion of Dkk2 in intestinal epithelial or stem cells reduced tumorigenesis as well as expression of the stem cell marker genes including Lgr5 in a model of colitis-associated cancer.

[Cell Death & Disease] Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.

[iScience] Elevation of Cdc42 activity in young animals by genetic means causes premature ISC aging, whereas pharmacological suppression of elevated Cdc42 activity restores organoid formation potential in vitro.

[American Journal of Physiology-Cell Physiology] Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.

[Cancer Research] The authors studied the impact of chemotherapy on Lgr5-expressing and MSI1-expressing cell populations and explored the effect of increased MSI1 levels in response to treatment.