MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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Camel Whey Protein Hydrolysates Induced G2/M Cellcycle Arrest in Human Colorectal Carcinoma

Peptides from milk proteins is gaining popularity in various therapeutics including human cancer. Researchers investigated the anti-cancerous and anti-inflammatory properties of camel whey protein hydrolysates
[Scientific Reports]
Murali, C., Mudgil, P., Gan, C.-Y., Tarazi, H., El-Awady, R., Abdalla, Y., Amin, A., & Maqsood, S. (2021). Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma. Scientific Reports, 11(1), 7062. https://doi.org/10.1038/s41598-021-86391-z Cite
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Pre-Clinical Small Molecule WEHI-7326 Overcomes Drug Resistance and Elicits Response in Patient-Derived Xenograft Models of Human Treatment-Refractory Tumors

Investigators describe results with a new anti-cancer small molecule, WEHI-7326, which caused cell cycle arrest in G2/M, cell death in vitro, and displayed efficacious anti-tumor activity in vivo.
[Cell Death & Disease]
Grohmann, C., Walker, F., Devlin, M., Luo, M.-X., Chüeh, A. C., Doherty, J., Vaillant, F., Ho, G.-Y., Wakefield, M. J., Weeden, C. E., Kamili, A., Murray, J., Po’uha, S. T., Weinstock, J., Kane, S. R., Faux, M. C., Broekhuizen, E., Zheng, Y., Shield-Artin, K., … Lessene, G. (2021). Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors. Cell Death & Disease, 12(3), 1–18. https://doi.org/10.1038/s41419-020-03269-0 Cite
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Signaling Pathways in Intestinal Homeostasis and Colorectal Cancer: KRAS at Centre Stage

Scientists summarize the signaling pathways contributing to intestinal cell fates and homeostasis functions, focusing on intestinal stem cell proliferation, cell junction formation, remodeling, hypoxia, the impact of intestinal microbiota, the immune system, inflammation, and metabolism.
[Cell Communication and Signaling]
Ternet, C., & Kiel, C. (2021). Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage. Cell Communication and Signaling, 19(1), 31. https://doi.org/10.1186/s12964-021-00712-3 Cite
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CDK1 Is Up-Regulated by Temozolomide in an NF-κB Dependent Manner in Glioblastoma

While cyclin-dependent kinase 1 (CDK1) phosphorylation is a well-described consequence of temozolomide (TMZ) treatment, researchers found that TMZ also robustly induced CDK1 expression.
[Scientific Reports]
Voce, D. J., Bernal, G. M., Cahill, K. E., Wu, L., Mansour, N., Crawley, C. D., Campbell, P.-A. S., Arina, A., Weichselbaum, R. R., & Yamini, B. (2021). CDK1 is up-regulated by temozolomide in an NF-κB dependent manner in glioblastoma. Scientific Reports, 11(1), 5665. https://doi.org/10.1038/s41598-021-84912-4 Cite
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Cdc6 Disruption Leads to Centrosome Abnormalities and Chromosome Instability in Pancreatic Cancer Cells

Cell division cycle 6 (Cdc6)-depleted pancreatic cancer cells significantly inhibited cell proliferation and colony formation, delayed G2/M cell cycle progression, and increased expression of p-histone H3 and cyclin A2 levels.
[Scientific Reports]
Youn, Y., Lee, J., Kim, J., Kim, J. H., & Hwang, J.-H. (2020). Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells. Scientific Reports, 10(1), 16518. https://doi.org/10.1038/s41598-020-73474-6 Cite
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Combination Therapy of Cold Atmospheric Plasma (CAP) With Temozolomide in the Treatment of U87MG Glioblastoma Cells

Investigators explored whether CAP, an ionized gas produced in laboratory settings and that operates at near room temperature, can enhance Temozolomide cytotoxicity on a glioblastoma cell line.
[Scientific Reports]
Raghuraman, S., Xie, J. Y., Giacobassi, M. J., Tun, J. O., Chase, K., Lu, D., Teichert, R. W., Porreca, F., & Olivera, B. M. (2020). Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1922618117 Cite
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MicroRNA-3148 Acts As Molecular Switch Promoting Malignant Transformation and Adipocytic Differentiation of Immortalized Human Bone Marrow Stromal Cells via Direct Targeting of the SMAD2/TGFβ Pathway

Scientists investigated the role of miR-3148 in regulating human stromal mesenchymal stem cell differentiation and transformation.
[Cell Death Discovery]
Vishnubalaji, R., Elango, R., Manikandan, M., Siyal, A.-A., Ali, D., Al-Rikabi, A., Hamam, D., Hamam, R., Benabdelkamel, H., Masood, A., Alanazi, I. O., Alfadda, A. A., Alfayez, M., Aldahmash, A., Kassem, M., & Alajez, N. M. (2020). MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway. Cell Death Discovery, 6(1), 1–16. https://doi.org/10.1038/s41420-020-00312-z Cite
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A Newly Isolated Strain of Halomonas sp. (HA1) Exerts Anticancer Potential via Induction of Apoptosis and G2/M Arrest in Hepatocellular Carcinoma (HepG2) Cell Line

Researchers suggested that the apoptotic and anti-proliferative effects of Halomonas sp. HA1 extracted on HepG2 cells can provide it as a candidate for future pharmaceutical industries.
[Scientific Reports]
El-Garawani, I. M., El-Sabbagh, S. M., Abbas, N. H., Ahmed, H. S., Eissa, O. A., Abo-Atya, D. M., Khalifa, S. A. M., & El-Seedi, H. R. (2020). A newly isolated strain of Halomonas sp. (HA1) exerts anticancer potential via induction of apoptosis and G 2 /M arrest in hepatocellular carcinoma (HepG2) cell line. Scientific Reports, 10(1), 14076. https://doi.org/10.1038/s41598-020-70945-8 Cite
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Lipid Composition of Liposomal Membrane Largely Affects Its Transport and Uptake through Small Intestinal Epithelial Cell Models

The authors investigated the transport and uptake of liposomes composed of docosahexaenoic acid‐enriched phosphatidylcholine, phosphatidylserine, and sulfoquinovosyl diacylglycerol derived from marine products on multilamellar vesicles in small intestinal epithelial cell models.
[Lipids]
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