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M cells

Aurora Kinase a Inhibition Induces Synthetic Lethality in SMAD4-Deficient Colorectal Cancer Cells via Spindle Assembly Checkpoint Activation

[Oncogene] Scientists performed a synthetic lethal drug screening with SMAD4-isogenic colorectal cancer cells and found that aurora kinase A inhibition is synthetic lethal with SMAD4 loss.

Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors

[Stem Cells Translational Medicine] Scientists discuss recent advances in understanding the mechanisms that regulate stem cell regeneration.

RNA-Seq of Nine Canine Prostate Cancer Cell Lines Reveals Diverse Therapeutic Target Signatures

[Cancer Cell International] Investigators compared the transcriptomes of nine canine cell lines derived from prostate adenocarcinoma (PAC), PAC metastasis and transitional cell carcinoma to their respective original primary tumor or metastasis tissues.

Stimulation of Motilin Secretion by Bile, Free Fatty Acids and Acidification in Human Duodenal Organoids

[Molecular Metabolism] Human duodenal organoids were CRISPR-Cas9 modified to express the fluorescent protein Venus or the Ca2+ sensor GCaMP7s under control of the endogenous motilin promoter.

CHK1 Inhibitor Sensitizes Resistant Colorectal Cancer Stem Cells to Nortopsentin

[iScience] Scientists reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analogue, Nortopsentin 234, led to an initial reduction of proliferative and clonogenic potential of colorectal cancer sphere cells (CR-CSphCs), followed by an adaptive response selecting the CR-CSphCs resistant compartment.

C646 Inhibits G2/M Cell Cycle-Related Proteins and Potentiates Anti-Tumor Effects in Pancreatic Cancer

[Scientific Reports] Investigators found that the histone acetyltransferases inhibitor C646 augmented anti-tumor effects in vitro by inhibiting cell proliferation and cell cycle progression concomitantly with suppression of acetylated H3K9 and H3K27 expression.

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