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MAPK

The Candida albicans Toxin Candidalysin Mediates Distinct Epithelial Inflammatory Responses through p38 and EGFR-ERK Pathways

[Science Signaling] In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos.

Palmitoylation Couples the Kinases DLK and JNK3 to Facilitate Prodegenerative Axon-to-Soma Signaling

[Science Signaling] Investigators identified two ways through which dual leucine-zipper kinase (DLK) was coupled to the neural-specific isoform c-Jun N-terminal kinase 3 (JNK3) to control prodegenerative signaling.

Low-Temperature Plasma-Activated Medium Inhibited Proliferation and Progression of Lung Cancer by Targeting the PI3K/Akt and MAPK Pathways

[Oxidative Medicine and Cellular Longevity] Scientists explored the effect of the plasma-activated medium on lung cancer cells in vitro and in vivo by using a 3D cell culture model.

Targeting Myeloid Derived Suppressor Cells Reverts Immune Suppression and Sensitizes BRAF-Mutant Papillary Thyroid Cancer to MAPK Inhibitors

[Nature Communications] Scientists demonstrated that BRAFV600E promoted thyroid cancer development by increasing myeloid-derived suppressor cells penetrance.

Histone Methyltransferase KMT2C Plays an Oncogenic Role in Prostate Cancer

[Journal of Cancer Research and Clinical Oncology] The authors assessed the function of KMT2C in prostate cancer cell proliferation, colony formation, and migration.

The Marine Factor 3,5-Dihydroxy-4-Methoxybenzyl Alcohol Suppresses Growth, Migration and Invasion and Stimulates Death of Metastatic Human Prostate Cancer Cells: Targeting Diverse Signaling Processes

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.

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